Anti-Tetanus Toxin antibody [TH-11] (ab278064)
![Western blot - Anti-Tetanus Toxin antibody [TH-11] (ab278064)](https://www.abcam.com/ps/products/278/ab278064/Images/ab278064-445342-anti-tetanus-toxin-antibody-th11-wb-tetanus-toxin.png "Western blot - Anti-Tetanus Toxin antibody [TH-11] (ab278064)")
Key features and details
- Mouse monoclonal [TH-11] to Tetanus Toxin
- Suitable for: WB
- Isotype: IgG1
Overview
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Product name
Anti-Tetanus Toxin antibody [TH-11]
See all Tetanus Toxin primary antibodies -
Description
Mouse monoclonal [TH-11] to Tetanus Toxin -
Host species
Mouse -
Tested applications
Suitable for: WBmore details -
Immunogen
Tissue, cells or virus corresponding to Tetanus Toxin. Clostridium tetani Harvard vaccine strain
Database link: P04958 -
Positive control
- WB:Tetanus Toxin.
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C. Avoid freeze / thaw cycle. -
Storage buffer
pH: 5
Constituents: 50% Glycerol (glycerin, glycerine), 50% PBS -
Concentration information loading... -
Purity
Protein G purified -
Clonality
Monoclonal -
Clone number
TH-11 -
Isotype
IgG1 -
Light chain type
kappa -
Research areas
Associated products
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Compatible Secondaries
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab278064 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| WB |
1/1000.
|
| Notes |
|---|
|
WB
1/1000. |
Target
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Relevance
Tetanus toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that catalyzes the hydrolysis of the 76-Gln-|-Phe-77 bond of synaptobrevin-2. The precursor polypeptide is subsequently cleaved to yield subchains L and H. These remain linked by a disulfide bridge and are non-toxic after separation. -
Cellular localization
Secreted -
Alternative names
- Tentoxylysin antibody
- Tetanus toxin chain H antibody
- Tetanus toxin chain L antibody
see all
Images
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Western blot - Anti-Tetanus Toxin antibody [TH-11] (ab278064)All lanes : Anti-Tetanus Toxin antibody [TH-11] (ab278064) at 1/1000 dilution
Lane 1 : Reduced tetanus toxin
Lane 2 : Un-reduced tetanus toxinTetanus toxin Heavy (H) and Light (L) chains
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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Datasheet download
References (0)
ab278064 has not yet been referenced specifically in any publications.
