Product nameTetrabenazine, VMAT2 inhibitor
DescriptionPotent, reversible VMAT2 inhibitor
Biological descriptionPotent, reversible VMAT2 inhibitor (IC50 = 3.2 nM, Ki = 100 nM). Depletes monoamines stores and decreases uptake into synaptic vesicles. Shows antihyperkinetic effects in vivo. Orally active.
Storage instructionsStore at Room Temperature. The product can be stored for up to 12 months.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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This product has been referenced in:
- Kuik WJ et al. In vivo biodistribution of no-carrier-added 6-18F-fluoro-3,4-dihydroxy-L-phenylalanine (18F-DOPA), produced by a new nucleophilic substitution approach, compared with carrier-added 18F-DOPA, prepared by conventional electrophilic substitution. J Nucl Med 56:106-12 (2015). Read more (PubMed: 25500826) »
- Deng A et al. Mapping the target localization and biodistribution of non-radiolabeled VMAT2 ligands in rat brain. AAPS J 16:592-9 (2014). Read more (PubMed: 24706374) »
- Randall PA et al. The VMAT-2 inhibitor tetrabenazine affects effort-related decision making in a progressive ratio/chow feeding choice task: reversal with antidepressant drugs. PLoS One 9:e99320 (2014). Read more (PubMed: 24937131) »