Tetracaine hydrochloride, allosteric RyR calcium channel blocke (ab143242)

Overview

  • Product name

    Tetracaine hydrochloride, allosteric RyR calcium channel blocke
  • Description

    Allosteric RyR calcium channel blocker. Potent local anesthetic and antipruritic effects.
  • Biological description

    Allosteric RyR calcium channel blocker. Shows potent local anesthetic and antipruritic effects in vivo. Reversibly inhibits AChE activity (IC50 = 40 μM).
  • Purity

    > 99%
  • CAS Number

    136-47-0
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    2-(Dimethylamino)ethyl 4-(butylamino)benzoate hydrochloride
  • Molecular weight

    300.82
  • Molecular formula

    C15H24N2O2.HCl
  • PubChem identifier

    8695
  • Storage instructions

    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water and in ethanol. Soluble in 0.1 N HCl
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Toxic, refer to SDS for further information.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CCCCNC1=CC=C(C=C1)C(=O)OCCN(C)C.Cl
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Tappeiner C  et al. Effect of topical anesthetic agents and ethanol on corneoepithelial wound healing in an ex vivo whole-globe porcine model. J Cataract Refract Surg 38:519-24 (2012). Read more (PubMed: 22245168) »
  • Xu DH  et al. Effect of receptor solution specific conductivity on iontophoresis of tetracaine hydrochloride. Yao Xue Xue Bao 39:144-8 (2004). Read more (PubMed: 15127625) »
  • al-Jafari AA  et al. Kinetics of the inhibition of acetylcholinesterase from desert cobra (Walterinnesia aegyptia) venom by local anesthetics: procaine and tetracaine. J Enzyme Inhib 11:123-34 (1996). Read more (PubMed: 9204401) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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