Tetracycline hydrochloride (aqueous), antibiotic (ab146579)

Overview

  • Product name

    Tetracycline hydrochloride (aqueous), antibiotic
  • Description

    Broad spectrum antibiotic.
  • Alternative names

    • Tetracycline HCl
  • Biological description

    Broad spectrum polyketide antibiotic with clinical uses in treating bacterial infections such as Rocky Mountain spotted fever, typush fever, tick fevers, Q fever, and Brill-Zinsser disease and to treat upper respiratory infections and acne.


    Tetracycline passively diffuses through protein channels in the cell membrane, binding to 30S ribosomes and inhibits protein synthesis by preventing access of aminoacyl tRNA to the acceptor site on the mRNA-ribosome complex. It also binds to the bacterial 50S ribosomal subunit, altering the membrane and causing intracellular components to leak from bacterial cells.

  • CAS Number

    64-75-5
  • Chemical structure

    Chemical Structure

Properties

  • Molecular weight

    480.90
  • Molecular formula

    C22H25ClN2O8
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Supplied in water (50 mg/ml)
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Synthetic

References

This product has been referenced in:

  • Kheadr E  et al. Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. Antimicrob Agents Chemother 51:169-74 (2007). Read more (PubMed: 17060530) »
  • Wu Y & Fassihi R Stability of metronidazole, tetracycline HCl and famotidine alone and in combination. Int J Pharm 290:1-13 (2005). Read more (PubMed: 15664125) »
  • Atrasheuskaya AV  et al. Changes in immune parameters and their correction in human cases of tick-borne encephalitis. Clin Exp Immunol 131:148-54 (2003). Read more (PubMed: 12519399) »

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