Product nameTetracycline hydrochloride (aqueous), antibiotic
DescriptionBroad spectrum antibiotic.
- Tetracycline HCl
Broad spectrum polyketide antibiotic with clinical uses in treating bacterial infections such as Rocky Mountain spotted fever, typush fever, tick fevers, Q fever, and Brill-Zinsser disease and to treat upper respiratory infections and acne.
Tetracycline passively diffuses through protein channels in the cell membrane, binding to 30S ribosomes and inhibits protein synthesis by preventing access of aminoacyl tRNA to the acceptor site on the mRNA-ribosome complex. It also binds to the bacterial 50S ribosomal subunit, altering the membrane and causing intracellular components to leak from bacterial cells.
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSupplied in water (50 mg/ml)
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
This product has been referenced in:
- Kheadr E et al. Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. Antimicrob Agents Chemother 51:169-74 (2007). Read more (PubMed: 17060530) »
- Wu Y & Fassihi R Stability of metronidazole, tetracycline HCl and famotidine alone and in combination. Int J Pharm 290:1-13 (2005). Read more (PubMed: 15664125) »
- Atrasheuskaya AV et al. Changes in immune parameters and their correction in human cases of tick-borne encephalitis. Clin Exp Immunol 131:148-54 (2003). Read more (PubMed: 12519399) »