Overview

  • Product name

    Tetrahydrouridine, cytidine deaminase inhibitor
  • Description

    Competitive cytidine deaminase inhibitor
  • Biological description

    Competitive cytidine deaminase inhibitor (IC50= 152 μM). Modulates antiproliferative effects. Orally active.
  • Purity

    > 80%
  • CAS Number

    18771-50-1
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    1-[3,4-Dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-hydroxy-1,3-diazinan-2-one
  • Molecular weight

    248.23
  • Molecular formula

    C9H16N2O6
  • PubChem identifier

    270480
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1CN(C(=O)NC1O)C2C(C(C(O2)CO)O)O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Timmers LF  et al. Combining molecular dynamics and docking simulations of the cytidine deaminase from Mycobacterium tuberculosis H37Rv. J Mol Model 18:467-79 (2012). Read more (PubMed: 21541749) »
  • Funamizu N  et al. Tetrahydrouridine inhibits cell proliferation through cell cycle regulation regardless of cytidine deaminase expression levels. PLoS One 7:e37424 (2012). Read more (PubMed: 22616006) »
  • Beumer JH  et al. Plasma pharmacokinetics and oral bioavailability of 3,4,5,6-tetrahydrouridine, a cytidine deaminase inhibitor, in mice. Cancer Chemother Pharmacol 62:457-64 (2008). Read more (PubMed: 18008070) »

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