Tetrandrine, Calcium channel blocker (ab142464)
- Datasheet
- References
Overview
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Product name
Tetrandrine, Calcium channel blocker -
Description
Calcium channel blocker. Anti-inflammatory and antitumor agent. -
Biological description
Calcium channel blocker. (IC50 values are 8 and 20 µM for L -type and T-type calcium channels respectively). Various pharmacological effects. Shows anti-inflammatory and antitumor activity. Inhibits osteoclast differentiation in vivo. Induces cell autophagy and ROS accumulation. Inhibits NF-κβ signaling. -
Purity
> 98% -
CAS Number
518-34-3 -
Chemical structure
Properties
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Chemical name
[4aS-(4aR*,16aR*)]-3,4,4a,5,16a,17,18,19-Octahydro-12,21,22,26-tetramethoxy-4,17-dimethyl-16H-1,24:6,9-dietheno-11,15-metheno-2H-pyrido[2',3':17,18][1,11]dioxacycloeicosino[2,3,4-ij]isoquinoline -
Molecular weight
622.75 -
Molecular formula
C38H42N2O6 -
PubChem identifier
73078 -
Storage instructions
Store at Room Temperature. The product can be stored for up to 12 months. -
Solubility overview
Soluble in ethanol to 5 mM and in DMSO to 5 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CN1CCC2=CC(=C3C=C2C1CC4=CC=C(C=C4)OC5=C(C=CC(=C5)CC6C7=C(O3)C(=C(C=C7CCN6C)OC)OC)OC)OC -
Source
Stephania tetrandra
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Research areas
References
This product has been referenced in:
- Gong K et al. Autophagy-related gene 7 (ATG7) and reactive oxygen species/extracellular signal-regulated kinase regulate tetrandrine-induced autophagy in human hepatocellular carcinoma. J Biol Chem 287:35576-88 (2012). Read more (PubMed: 22927446) »
- Takahashi T et al. Tetrandrine prevents bone loss in sciatic-neurectomized mice and inhibits receptor activator of nuclear factor ?B ligand-induced osteoclast differentiation. Biol Pharm Bull 35:1765-74 (2012). Read more (PubMed: 23037166) »
- Wu CJ et al. Tetrandrine down-regulates ERK/NF-?B signaling and inhibits activation of mesangial cells. Toxicol In Vitro 25:1834-40 (2011). Read more (PubMed: 22001142) »
- Dworetzky SI et al. Phenotypic alteration of a human BK (hSlo) channel by hSlobeta subunit coexpression: changes in blocker sensitivity, activation/relaxation and inactivation kinetics, and protein kinase A modulation. J Neurosci 16:4543-50 (1996). Read more (PubMed: 8764643) »
