Overview

  • Product name

    Tetrandrine, Calcium channel blocker
  • Description

    Calcium channel blocker. Anti-inflammatory and antitumor agent.
  • Biological description

    Calcium channel blocker. (IC50 values are 8 and 20 µM for L -type and T-type calcium channels respectively). Various pharmacological effects. Shows anti-inflammatory and antitumor activity. Inhibits osteoclast differentiation in vivo. Induces cell autophagy and ROS accumulation. Inhibits NF-κβ signaling.
  • Purity

    > 98%
  • CAS Number

    518-34-3
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Gong K  et al. Autophagy-related gene 7 (ATG7) and reactive oxygen species/extracellular signal-regulated kinase regulate tetrandrine-induced autophagy in human hepatocellular carcinoma. J Biol Chem 287:35576-88 (2012). Read more (PubMed: 22927446) »
  • Takahashi T  et al. Tetrandrine prevents bone loss in sciatic-neurectomized mice and inhibits receptor activator of nuclear factor ?B ligand-induced osteoclast differentiation. Biol Pharm Bull 35:1765-74 (2012). Read more (PubMed: 23037166) »
  • Wu CJ  et al. Tetrandrine down-regulates ERK/NF-?B signaling and inhibits activation of mesangial cells. Toxicol In Vitro 25:1834-40 (2011). Read more (PubMed: 22001142) »
  • Dworetzky SI  et al. Phenotypic alteration of a human BK (hSlo) channel by hSlobeta subunit coexpression: changes in blocker sensitivity, activation/relaxation and inactivation kinetics, and protein kinase A modulation. J Neurosci 16:4543-50 (1996). Read more (PubMed: 8764643) »

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