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    tetrandrine-calcium-channel-blocker-ab142464.pdf

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Tetrandrine, Calcium channel blocker (ab142464)

  • Datasheet
  • SDS
  • COA
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  • Datasheet
  • References

Overview

  • Product name

    Tetrandrine, Calcium channel blocker
  • Description

    Calcium channel blocker. Anti-inflammatory and antitumor agent.
  • Biological description

    Calcium channel blocker. (IC50 values are 8 and 20 µM for L -type and T-type calcium channels respectively). Various pharmacological effects. Shows anti-inflammatory and antitumor activity. Inhibits osteoclast differentiation in vivo. Induces cell autophagy and ROS accumulation. Inhibits NF-κβ signaling.
  • Purity

    > 98%
  • CAS Number

    518-34-3
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    [4aS-(4aR*,16aR*)]-3,4,4a,5,16a,17,18,19-Octahydro-12,21,22,26-tetramethoxy-4,17-dimethyl-16H-1,24:6,9-dietheno-11,15-metheno-2H-pyrido[2',3':17,18][1,11]dioxacycloeicosino[2,3,4-ij]isoquinoline
  • Molecular weight

    622.75
  • Molecular formula

    C38H42N2O6
  • PubChem identifier

    73078
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in ethanol to 5 mM and in DMSO to 5 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CN1CCC2=CC(=C3C=C2C1CC4=CC=C(C=C4)OC5=C(C=CC(=C5)CC6C7=C(O3)C(=C(C=C7CCN6C)OC)OC)OC)OC
  • Source

    Stephania tetrandra

  • Research areas

    • Biochemicals
    • Product Range
    • New
    • Biochemicals
    • Chemical Type
    • Biochemicals
    • Biochemicals
    • Pharmacology
    • Signaling
    • Immunomodulators
    • Biochemicals
    • Pharmacology
    • Signaling
    • Apoptosis & cell cycle
    • Other
    • Biochemicals
    • Pharmacology
    • Ion Channels
    • Calcium
    • Blockers
    • Biochemicals
    • Pharmacology
    • Signaling
    • Signal transduction
    • Cytokines, NF-κB & IκB signaling
    • Biochemicals
    • Pharmacology
    • Signaling
    • Immunomodulators
    • Immunomodulators & Immunosuppressants

Datasheets and documents

    • Datasheet
    • SDS
    • COA
  • References

    This product has been referenced in:

    • Gong K  et al. Autophagy-related gene 7 (ATG7) and reactive oxygen species/extracellular signal-regulated kinase regulate tetrandrine-induced autophagy in human hepatocellular carcinoma. J Biol Chem 287:35576-88 (2012). Read more (PubMed: 22927446) »
    • Takahashi T  et al. Tetrandrine prevents bone loss in sciatic-neurectomized mice and inhibits receptor activator of nuclear factor ?B ligand-induced osteoclast differentiation. Biol Pharm Bull 35:1765-74 (2012). Read more (PubMed: 23037166) »
    • Wu CJ  et al. Tetrandrine down-regulates ERK/NF-?B signaling and inhibits activation of mesangial cells. Toxicol In Vitro 25:1834-40 (2011). Read more (PubMed: 22001142) »
    • Dworetzky SI  et al. Phenotypic alteration of a human BK (hSlo) channel by hSlobeta subunit coexpression: changes in blocker sensitivity, activation/relaxation and inactivation kinetics, and protein kinase A modulation. J Neurosci 16:4543-50 (1996). Read more (PubMed: 8764643) »

    Publishing research using ab142464? Please let us know so that we can cite the reference in this datasheet.

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