Key features and details
- Na+ channel blocker; water-soluble
- CAS Number: 18660-81-6
Soluble in water
- Form / State: Solid
- Source: Fugu
Product nameTetrodotoxin citrate, Na+ channel blocker
DescriptionNa+ channel blocker; water-soluble
- TTX citrate
Water soluble citrate salt of tetrodotoxin. Potent, selective and reversible, use-dependent inhibitor of voltage-dependent Na+ channels.
The vial will contain 1 mg of TTX and an additional 5 mg of citrate buffer to aid with solubility. For calculations relating to TTX concentration, refer to the molecular weight 319.27 listed on the vial.
Item is subject to Export Control Regulations and Licensing requirements. Please contact Customer Service for more information and lead times.
Octahydro-12-(hydroxymethyl)-2-imino-5,9:7,10a-dimethano-10aH-[1,3]dioxocino[6,5-d] pyrimidine-4,7,10,11,12-pentol + citrate buffer
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Soluble in water
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
2D chemical structure image of ab120055, Tetrodotoxin citrate, Na+ channel blocker
Percent of TTX-containing food pellets eaten by bluegill over 6 d of repeated feedings.
Pellets were infused with different concentrations of TTX within the range found in newts from the field. P values are from likelihood ratio tests from a GLMM.
Cell-attached recording of a striatal cholinergic interneuron depicting TTX (100 nM) inhibition of spontaneous action potential firing. The open bar indicates time of TTX application.
Quantification of the p-S6rp signal in each striatal ChAt immunoreactive neuron after 1 hour incubation in control or TTX (1 M). Each dot corresponds to one neuron; each color corresponds to a different animal; dashed lines indicate the mean. Fluorescence values are normalized in arbitrary units (a.u.).
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab120055 has been referenced in 129 publications.
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- Hughson BN et al. AKH Signaling in D. melanogaster Alters Larval Development in a Nutrient-Dependent Manner That Influences Adult Metabolism. Front Physiol 12:619219 (2021). PubMed: 33708137
- Chang DF et al. NH2-terminal deletion of specific phosphorylation sites on PHOX2B disrupts the formation of enteric neurons in vivo. Am J Physiol Gastrointest Liver Physiol 320:G1054-G1066 (2021). PubMed: 33881351