Overview

  • Product name
    Tetrodotoxin citrate, Na+ channel blocker
  • Description
    Na+ channel blocker; water-soluble
  • Alternative names
    • TTX
    • TTX citrate
  • Biological description
    Water soluble citrate salt of tetrodotoxin. Potent, selective and reversible, use-dependent inhibitor of voltage-dependent Na+ channels.
  • Purity
    > 98%
  • General notes
    To purchase this product, additional information may be required for security reasons. Please contact customer services for further details.
  • CAS Number
    18660-81-6
  • Chemical structure
    Chemical Structure

Properties

Images

  • Percent of TTX-containing food pellets eaten by bluegill over 6 d of repeated feedings.

    Pellets were infused with different concentrations of TTX within the range found in newts from the field. P values are from likelihood ratio tests from a GLMM.

  • Cell-attached recording of a striatal cholinergic interneuron depicting TTX (100 nM) inhibition of spontaneous action potential firing. The open bar indicates time of TTX application.
  • Quantification of the p-S6rp signal in each striatal ChAt immunoreactive neuron after 1 hour incubation in control or TTX (1 M). Each dot corresponds to one neuron; each color corresponds to a different animal; dashed lines indicate the mean. Fluorescence values are normalized in arbitrary units (a.u.).

References

This product has been referenced in:
See all 64 Publications for this product

Customer reviews and Q&As

1-3 of 3 Abreviews or Q&A

Answer

The water-soluble TTX citrate ab120055 is not a citrate salt, it is simply TTX that has been dissolved in a citrate solution, and then lyophilized. So, it has the same molecular weight and formula as ab120054, which is soluble in pH 4.8 citrate buffer to 100 mM.

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Answer


I contacted the laboratory regarding the difference between ab120054 and ab120055, and they responded that the only difference between these two compounds is that TTX citrate (ab120055) is the water soluble version, which accounts for the difference in price.

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Answer

Tetrodotoxin is very toxic and should be handled with caution. The safety datasheet is available from the datasheet.

Additionally, to neutralize the toxin, you may use a freshly made solution of 0.25% NaOCl + 0.25 N NaOH or a solution of 0.5% NaOCl. Allow a 30 minute contact time. The spill must then cleaned up using absorbent material. The area must be further washed using a soapy solution to remove any residues. The spill material should be collected and disposed of as hazardous waste.

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