Overview

  • Product name

  • Description

    Goat polyclonal to TFB2M
  • Host species

    Goat
  • Tested applications

    Suitable for: ICC/IF, WBmore details
  • Species reactivity

    Reacts with: Rat, Human
  • Immunogen

    Synthetic peptide:

    CAYKWLYDETLEDR

    , corresponding to C terminal amino acids 383-396 of Human TFB2M.

  • General notes

    GenBank Accession Number - NP_071761

Properties

Applications

Our Abpromise guarantee covers the use of ab13676 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF Use at an assay dependent dilution. PubMed: 21113058
WB Use at an assay dependent dilution. Preliminary experiments gave an approx 40kDa band in Human Brain lysate at 0.3 ug/ml. Please note that currently we cannot find an explanation in the literature for the band we observe given the predicted size of approx. 46kDda according to NP_071761

Target

  • Function

    S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity. Compared to TFB1M, it activates transcription of mitochondrial DNA more efficiently, while it has less methyltransferase activity.
  • Tissue specificity

    Ubiquitously expressed.
  • Sequence similarities

    Belongs to the methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. KsgA subfamily.
  • Cellular localization

    Mitochondrion.
  • Information by UniProt
  • Database links

  • Alternative names

    • N''-adenosyl(rRNA) dimethyltransferase 2 antibody
    • S adenosylmethionine 6 N', N' adenosyl(rRNA) dimethyltransferase 2 antibody
    • Dimethyladenosine transferase 2 antibody
    • dimethyladenosine transferase 2 mitochondrial antibody
    • FLJ22661 antibody
    • FLJ23182 antibody
    • h mtTFB antibody
    • h mtTFB2 antibody
    • h-mtTFB antibody
    • h-mtTFB2 antibody
    • HCV NS5A transactivated protein 5 antibody
    • HCV NS5A-transactivated protein 5 antibody
    • hepatitis C virus NS5A transactivated protein 5 antibody
    • Hepatitis C virus NS5A-transactivated protein 5 antibody
    • Hkp1 antibody
    • hTFB2M antibody
    • Mitochondrial 12S rRNA dimethylase 2 antibody
    • mitochondrial antibody
    • Mitochondrial dimethyladenosine transferase 2 antibody
    • Mitochondrial transcription factor B2 antibody
    • mtTFB antibody
    • mtTFB2 antibody
    • NS5ATP5 antibody
    • S-adenosylmethionine-6-N'' antibody
    • TFB2M antibody
    • TFB2M_HUMAN antibody
    • Transcription Factor B2 antibody
    • Transcription factor B2 mitochondrial antibody
    see all

References

This product has been referenced in:

  • Radhakrishnan J  et al. Cyclophilin-D: a resident regulator of mitochondrial gene expression. FASEB J 29:2734-48 (2015). Read more (PubMed: 25837584) »
  • Watanabe A  et al. Mitochondrial transcription factors TFAM and TFB2M regulate Serca2 gene transcription. Cardiovasc Res 90:57-67 (2011). ICC/IF ; Rat . Read more (PubMed: 21113058) »
See all 3 Publications for this product

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