Key features and details
- Rabbit polyclonal to TGE - C-terminal
- Suitable for: IHC-P
- Reacts with: Mouse, Rat, Human
- Isotype: IgG
Product nameAnti-TGE antibody - C-terminal
See all TGE primary antibodies
DescriptionRabbit polyclonal to TGE - C-terminal
Tested applicationsSuitable for: IHC-Pmore details
Species reactivityReacts with: Mouse, Rat, Human
Protein previously labeled as Transglutaminase 3.
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferPreservative: 0.09% Sodium azide
Constituents: 0.01% BSA, 50% Glycerol
Aqueous buffered solution.
Concentration information loading...
PurityProtein A purified
Our Abpromise guarantee covers the use of ab203229 in the following tested applications.
|IHC-P||1/100 - 1/500.
(or 1/50 – 1/200 using a fluorescent secondary antibody).
FunctionCatalyzes the calcium-dependent formation of isopeptide cross-links between glutamine and lysine residues in various proteins, as well as the conjugation of polyamines to proteins. Involved in the formation of the cornified envelope (CE), a specialized component consisting of covalent cross-links of proteins beneath the plasma membrane of terminally differentiated keratinocytes. Catalyzes small proline-rich proteins (SPRR1 and SPRR2) and LOR cross-linking to form small interchain oligomers, which are further cross-linked by TGM1 onto the growing CE scaffold (By similarity). In hair follicles, involved in cross-linking structural proteins to hardening the inner root sheath.
Sequence similaritiesBelongs to the transglutaminase superfamily. Transglutaminase family.
modificationsActivated by proteolytic processing. In vitro activation is commonly achieved by cleavage with dispase, a neutral bacterial protease. Dispase cleavage site was proposed to lie between Ser-470 and Ser-471 (PubMed:8099584) or between Pro-465 and Phe-466 (PubMed:16565075). Physiological activation may be catalyzed by CTSL and, to a lesser extent, by CTSS, but not by CTSB, CTSD nor CTSV (PubMed:16565075).
- Information by UniProt
- E polypeptide protein glutamine gamma glutamyltransferase antibody
- MGC126249 antibody
- MGC126250 antibody
ab203229 has not yet been referenced specifically in any publications.