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    tgf-beta-2-antibody-ab167655.pdf

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Signal Transduction Growth Factors/Hormones TGF
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Anti-TGF beta 2 antibody (ab167655)

  • Datasheet
Submit a review Submit a question References (3)

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Western blot - Anti-TGF beta 2 antibody (ab167655)

    Key features and details

    • Mouse polyclonal to TGF beta 2
    • Suitable for: WB
    • Reacts with: Human
    • Isotype: IgG

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    Overview

    • Product name

      Anti-TGF beta 2 antibody
      See all TGF beta 2 primary antibodies
    • Description

      Mouse polyclonal to TGF beta 2
    • Host species

      Mouse
    • Tested applications

      Suitable for: WBmore details
    • Species reactivity

      Reacts with: Human
      Predicted to work with: Rabbit, Horse, Cow, Dog, Chimpanzee, Rhesus monkey
    • Immunogen

      Recombinant full length protein, corresponding to amino acids 1-414 of Human TGF beta 2 (AAH99635.1).

      Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI
    • Positive control

      • TGF beta 2 transfected 293T cell lysate
    • General notes

      The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

      If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As

    Properties

    • Form

      Liquid
    • Storage instructions

      Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
    • Storage buffer

      pH: 7.4
      Constituent: 100% PBS
    • Concentration information loading...
    • Purity

      Protein A purified
    • Clonality

      Polyclonal
    • Isotype

      IgG
    • Research areas

      • Signal Transduction
      • Growth Factors/Hormones
      • TGF
      • Stem Cells
      • Signaling Pathways
      • TGF beta
      • Secreted
      • Cancer
      • Growth factors
      • TGF
      • Cancer
      • Invasion/microenvironment
      • Angiogenesis
      • Angiogenic growth factors
      • Cancer
      • Cancer Metabolism
      • Response to hypoxia
      • Metabolism
      • Pathways and Processes
      • Metabolism processes
      • Hypoxia

    Associated products

    • Compatible Secondaries

      • Goat Anti-Mouse IgG H&L (Alexa Fluor® 488) (ab150113)
      • Goat Anti-Mouse IgG H&L (HRP) (ab205719)
    • Isotype control

      • Mouse IgG - Isotype Control (ab37355)
    • Recombinant Protein

      • Recombinant human TGF beta 2 protein (Active) (ab84070)

    Applications

    The Abpromise guarantee

    Our Abpromise guarantee covers the use of ab167655 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Abreviews Notes
    WB
    Use a concentration of 1 µg/ml. Predicted molecular weight: 48 kDa.
    Notes
    WB
    Use a concentration of 1 µg/ml. Predicted molecular weight: 48 kDa.

    Target

    • Function

      TGF-beta 2 has suppressive effects on interleukin-2 dependent T-cell growth.
    • Involvement in disease

      A chromosomal aberration involving TGFB2 is found in a family with Peters anomaly. Translocation t(1;7)(q41;p21) with HDAC9.
      Loeys-Dietz syndrome 4
      Defects in TGFB2 may be a cause of non-syndromic aortic disease (NSAD). NSAD is a frequently asymptomatic but potentially lethal disease characterized by thoracic aortic aneurysms and dissections without additional syndromic features.
    • Sequence similarities

      Belongs to the TGF-beta family.
    • Post-translational
      modifications

      The precursor is cleaved into mature TGF-beta-2 and LAP, which remains non-covalently linked to mature TGF-beta-2 rendering it inactive.
    • Cellular localization

      Secreted.
    • Target information above from: UniProt accession P61812 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt
    • Database links

      • Entrez Gene: 534069 Cow
      • Entrez Gene: 7040 Human
      • Entrez Gene: 7042 Human
      • Entrez Gene: 7043 Human
      • Entrez Gene: 100009371 Rabbit
      • Omim: 190220 Human
      • SwissProt: P21214 Cow
      • SwissProt: P01137 Human
      • SwissProt: P10600 Human
      • SwissProt: P61812 Human
      • Unigene: 133379 Human
      • Unigene: 592317 Human
      • Unigene: 645227 Human
      • Unigene: 713281 Human
      see all
    • Alternative names

      • BSC-1 cell growth inhibitor antibody
      • BSC1 cell growth inhibitor antibody
      • Cetermin antibody
      • G-TSF antibody
      • Glioblastoma-derived T-cell suppressor factor antibody
      • GTSF antibody
      • LAP antibody
      • Latency-associated peptide antibody
      • MGC116892 antibody
      • MGF antibody
      • Milk growth factor antibody
      • Polyergin antibody
      • TGF-beta-2 antibody
      • TGF-beta2 antibody
      • TGFB2 antibody
      • TGFB2_HUMAN antibody
      • Transforming growth factor beta 2 antibody
      see all

    Images

    • Western blot - Anti-TGF beta 2 antibody (ab167655)
      Western blot - Anti-TGF beta 2 antibody (ab167655)
      All lanes : Anti-TGF beta 2 antibody (ab167655) at 1 µg/ml

      Lane 1 : TGF beta 2 transfected 293T cell lysate
      Lane 2 : Non-transfected 293T cell lysate

      Lysates/proteins at 15 µl per lane.

      Secondary
      All lanes : Goat Anti-Mouse IgG HRP at 1/2500 dilution

      Predicted band size: 48 kDa

    Protocols

    • Western blot protocols

    Click here to view the general protocols

    Datasheets and documents

    • Datasheet download

      Download

    References (3)

    Publishing research using ab167655? Please let us know so that we can cite the reference in this datasheet.

    ab167655 has been referenced in 3 publications.

    • Song L  et al. Phytosterol esters attenuate hepatic steatosis in rats with non-alcoholic fatty liver disease rats fed a high-fat diet. Sci Rep 7:41604 (2017). WB ; Rat . PubMed: 28169366
    • Zhuang R  et al. CR6-interacting factor 1 inhibits invasiveness by suppressing TGF-ß-mediated epithelial-mesenchymal transition in hepatocellular carcinoma. Oncotarget 8:94759-94768 (2017). PubMed: 29212264
    • Liu Y  et al. RUNX3 modulates hypoxia-induced endothelial-to-mesenchymal transition of human cardiac microvascular endothelial cells. Int J Mol Med 40:65-74 (2017). PubMed: 28534977

    Customer reviews and Q&As

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