Overview

  • Product name
  • Description
    Mouse polyclonal to TGF beta 2
  • Host species
    Mouse
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human, Pig
    Predicted to work with: Rabbit, Horse, Cow, Dog, Chimpanzee, Rhesus monkey
  • Immunogen

    Recombinant full length protein, corresponding to amino acids 1-414 of Human TGF beta 2 (AAH99635.1).

  • Positive control
    • TGF beta 2 transfected 293T cell lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab167655 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 48 kDa.

Target

  • Function
    TGF-beta 2 has suppressive effects on interleukin-2 dependent T-cell growth.
  • Involvement in disease
    A chromosomal aberration involving TGFB2 is found in a family with Peters anomaly. Translocation t(1;7)(q41;p21) with HDAC9.
    Loeys-Dietz syndrome 4
    Defects in TGFB2 may be a cause of non-syndromic aortic disease (NSAD). NSAD is a frequently asymptomatic but potentially lethal disease characterized by thoracic aortic aneurysms and dissections without additional syndromic features.
  • Sequence similarities
    Belongs to the TGF-beta family.
  • Post-translational
    modifications
    The precursor is cleaved into mature TGF-beta-2 and LAP, which remains non-covalently linked to mature TGF-beta-2 rendering it inactive.
  • Cellular localization
    Secreted.
  • Information by UniProt
  • Database links
  • Alternative names
    • BSC-1 cell growth inhibitor antibody
    • BSC1 cell growth inhibitor antibody
    • Cetermin antibody
    • G-TSF antibody
    • Glioblastoma-derived T-cell suppressor factor antibody
    • GTSF antibody
    • LAP antibody
    • Latency-associated peptide antibody
    • MGC116892 antibody
    • MGF antibody
    • Milk growth factor antibody
    • Polyergin antibody
    • TGF-beta-2 antibody
    • TGF-beta2 antibody
    • TGFB2 antibody
    • TGFB2_HUMAN antibody
    • Transforming growth factor beta 2 antibody
    see all

Images

  • All lanes : Anti-TGF beta 2 antibody (ab167655) at 1 µg/ml

    Lane 1 : TGF beta 2 transfected 293T cell lysate
    Lane 2 : Non-transfected 293T cell lysate

    Lysates/proteins at 15 µl per lane.

    Secondary
    All lanes : Goat Anti-Mouse IgG HRP at 1/2500 dilution

    Predicted band size: 48 kDa

References

This product has been referenced in:
  • Song L  et al. Phytosterol esters attenuate hepatic steatosis in rats with non-alcoholic fatty liver disease rats fed a high-fat diet. Sci Rep 7:41604 (2017). WB ; Rat . Read more (PubMed: 28169366) »
  • Zhuang R  et al. CR6-interacting factor 1 inhibits invasiveness by suppressing TGF-ß-mediated epithelial-mesenchymal transition in hepatocellular carcinoma. Oncotarget 8:94759-94768 (2017). Read more (PubMed: 29212264) »
See all 3 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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