Anti-TGF beta 2 antibody (ab81076)

Rabbit polyclonal TGF beta 2 antibody. Validated in IHC and tested in Human.

Overview

  • Product name

  • Description

    Rabbit polyclonal to TGF beta 2
  • Host species

    Rabbit
  • Specificity

    ab81076 antibody reacts with the precursor and mature form of TGF beta 2 and to a lesser extent TGF beta 3, but does not cross react with TGF beta 1.
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Synthetic peptide within Human TGF beta 2 aa 350 to the C-terminus (internal sequence). The exact sequence is proprietary.
    Database link: P61812

  • Positive control

    • Placenta

Properties

Applications

Our Abpromise guarantee covers the use of ab81076 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/100. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.

1/100 for 30 min at RT. Perform heat mediated antigen retrieval before commencing with IHC staining protocol, by boiling tissue sections in 10mM Citrate buffer, pH 6.0 for 10 min followed by cooling at RT for 20 min.

Target

  • Function

    TGF-beta 2 has suppressive effects on interleukin-2 dependent T-cell growth.
  • Involvement in disease

    A chromosomal aberration involving TGFB2 is found in a family with Peters anomaly. Translocation t(1;7)(q41;p21) with HDAC9.
    Loeys-Dietz syndrome 4
    Defects in TGFB2 may be a cause of non-syndromic aortic disease (NSAD). NSAD is a frequently asymptomatic but potentially lethal disease characterized by thoracic aortic aneurysms and dissections without additional syndromic features.
  • Sequence similarities

    Belongs to the TGF-beta family.
  • Post-translational
    modifications

    The precursor is cleaved into mature TGF-beta-2 and LAP, which remains non-covalently linked to mature TGF-beta-2 rendering it inactive.
  • Cellular localization

    Secreted.
  • Information by UniProt
  • Database links

  • Alternative names

    • BSC-1 cell growth inhibitor antibody
    • BSC1 cell growth inhibitor antibody
    • Cetermin antibody
    • G-TSF antibody
    • Glioblastoma-derived T-cell suppressor factor antibody
    • GTSF antibody
    • LAP antibody
    • Latency-associated peptide antibody
    • MGC116892 antibody
    • MGF antibody
    • Milk growth factor antibody
    • Polyergin antibody
    • TGF-beta-2 antibody
    • TGF-beta2 antibody
    • TGFB2 antibody
    • TGFB2_HUMAN antibody
    • Transforming growth factor beta 2 antibody
    see all

Images

  • Immunohistochemistry analysis of formalin-fixed, paraffin-embedded Human placenta tissue, using 1/100 ab81076.

References

ab81076 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab81076.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
For licensing inquiries, please contact partnerships@abcam.com

Sign up