Key features and details
- Rabbit polyclonal to TGF beta 3
- Suitable for: WB, ELISA
- Reacts with: Human
- Isotype: IgG
Product nameAnti-TGF beta 3 antibody
See all TGF beta 3 primary antibodies
DescriptionRabbit polyclonal to TGF beta 3
SpecificityDetects endogenous levels of total TGF ß3 protein.
Tested applicationsSuitable for: WB, ELISAmore details
Species reactivityReacts with: Human
Predicted to work with: Mouse, Rat
Synthetic peptide derived from human TGF ß3.
- Extracts from COS7 cells.
Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage bufferpH: 7.40
Preservative: 0.02% Sodium azide
Constituents: 50% Glycerol, 0.87% Sodium chloride, PBS
Without Mg+2 and Ca+2
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab53727 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/500 - 1/1000. Predicted molecular weight: 47 kDa.|
FunctionInvolved in embryogenesis and cell differentiation.
Involvement in diseaseDefects in TGFB3 are a cause of familial arrhythmogenic right ventricular dysplasia type 1 (ARVD1) [MIM:107970]; also known as arrhythmogenic right ventricular cardiomyopathy 1 (ARVC1). ARVD is an autosomal dominant disease characterized by partial degeneration of the myocardium of the right ventricle, electrical instability, and sudden death. It is clinically defined by electrocardiographic and angiographic criteria; pathologic findings, replacement of ventricular myocardium with fatty and fibrous elements, preferentially involve the right ventricular free wall.
Sequence similaritiesBelongs to the TGF-beta family.
- Information by UniProt
- ARVD antibody
- ARVD1 antibody
- FLJ16571 antibody
All lanes : Anti-TGF beta 3 antibody (ab53727) at 1/500 dilution
Lane 1 : extracts from COS7 cells
Lane 2 : extracts from COS7 cells with immunizing peptide
Performed under reducing conditions.
Predicted band size: 47 kDa
Observed band size: 11 kDa why is the actual band size different from the predicted?
Additional bands at: 65 kDa (possible non-specific binding)
The active molecule is a nonglycosylated, homodimer comprised of 13-kDa polypeptide chains linked by disulphide bonds.
ab53727 has not yet been referenced specifically in any publications.