Anti-TGFBRAP1 antibody (ab122468)

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Overview

  • Product name

    Anti-TGFBRAP1 antibody
    See all TGFBRAP1 primary antibodies

  • Description

    Rabbit polyclonal to TGFBRAP1

  • Host species

    Rabbit

  • Tested applications

    Suitable for: IHC-P, WBmore details

  • Species reactivity

    Reacts with: Human

  • Immunogen

    Recombinant fragment corresponding to Human TGFBRAP1 aa 712-807 (internal sequence).
    Sequence:

    RQQLFHTLLAIYLHAGPTAHELAVAAVDLLNRHATEFDAAQVLQMLPDTW SVQLLCPFLMGAMRDSIHARRTMQVALGLARSENLIYTYDKMKLKG

    Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI

  • Positive control

    • Human pancreas tissue; RT 4 and U 251 MG cell lysates.

  • General notes

    Previously labelled as TGF-beta receptor-associated protein 1.

Properties

Applications

Our Abpromise guarantee covers the use of ab122468 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/10 - 1/20. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
WB 1/250 - 1/500.

Target

  • Function

    Plays a role in the TGF-beta/activin signaling pathway. It associates with inactive heteromeric TGF-beta and activin receptor complexes, mainly through the type II receptor, and is released upon activation of signaling. May recruit SMAD4 to the vicinity of the receptor complex and facilitate its interaction with receptor-regulated Smads, such as SMAD2.

  • Sequence similarities

    Belongs to the TRAP1 family.
    Contains 1 CNH domain.

  • Cellular localization

    Cytoplasm. Colocalizes with TGF-beta receptors in the absence of signaling.
  • Information by UniProt

  • Database links

    • Alternative names

      • TGF-beta receptor-associated protein 1 antibody
      • TGFA1_HUMAN antibody
      • Tgfbrap1 antibody
      • Transforming growth factor-beta receptor-associated protein 1 antibody
      • TRAP-1 antibody
      • TRAP1 antibody
      • VPS3 antibody
      see all

    Images

    • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TGFBRAP1 antibody (ab122468)
      Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TGFBRAP1 antibody (ab122468)

      ab122468, at 1/10 dilution, staining TGFBRAP1 in paraffin-embedded Human pancreas tissue by Immunohistochemistry.

    • Western blot - Anti-TGFBRAP1 antibody (ab122468)
      Western blot - Anti-TGFBRAP1 antibody (ab122468)
      All lanes : Anti-TGFBRAP1 antibody (ab122468) at 1/250 dilution

      Lane 1 : RT 4 cell lysate
      Lane 2 : U 251 MG cell lysate
      Lane 3 : Human plasma lysate
      Lane 4 : Human liver tissue lysate
      Lane 5 : Human tonsil tissue lysate

      Developed using the ECL technique.

    References

    ab122468 has not yet been referenced specifically in any publications.

    Publishing research using ab122468? Please let us know so that we can cite the reference in this datasheet.

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