Key features and details
- Potent, selective TGR5 G-protein coupled receptor agonist
- CAS Number: 1197300-24-5
- Purity: > 99%
- Soluble in ethanol to 100 mM and in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Product nameTGR5 Receptor Agonist, TGR5 G-protein coupled receptor agonist
DescriptionPotent, selective TGR5 G-protein coupled receptor agonist
Potent, selective TGR5 G-protein coupled receptor agonist (pEC50 = 6.8). Increases glucagon-like peptide-1 (GLP-1) secretion from primary intestinal cells. Cell-permeable. Active in vivo.
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in ethanol to 100 mM and in DMSO to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab142091 has been referenced in 1 publication.
- Tremblay S et al. Bile Acid Administration Elicits an Intestinal Antimicrobial Program and Reduces the Bacterial Burden in Two Mouse Models of Enteric Infection. Infect Immun 85:N/A (2017). PubMed: 28348052