Overview

  • Product name

  • Description

    Rabbit polyclonal to Themis
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Synthetic peptide within Human Themis aa 300-350 conjugated to keyhole limpet haemocyanin. The exact sequence is proprietary.
    Database link: Q8N1K5

  • Positive control

    • Human kidney tissues.

Properties

Applications

Our Abpromise guarantee covers the use of ab217017 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/100 - 1/500.

Target

  • Function

    Plays a central role in late thymocyte development by controlling both positive and negative T-cell selection. Required to sustain and/or integrate signals required for proper lineage commitment and maturation of T-cells. Regulates T-cell development through T-cell antigen receptor (TCR) signaling and in particular through the regulation of calcium influx and phosphorylation of Erk.
  • Sequence similarities

    Belongs to the themis family.
  • Post-translational
    modifications

    Phosphorylated on Tyr residues quickly after TCR stimulation.
  • Cellular localization

    Cytoplasm. Nucleus.
  • Information by UniProt
  • Database links

  • Alternative names

    • C6orf190 antibody
    • C6orf207 antibody
    • MGC163388 antibody
    • Protein THEMIS antibody
    • SIGNALING PHOSPHOPROTEIN SPECIFIC FOR T CELLS antibody
    • SPOT antibody
    • THEMIS antibody
    • THMS1_HUMAN antibody
    • Thymocyte expressed molecule involved in selection antibody
    • Thymocyte selection associated antibody
    • Thymocyte selection pathway associated antibody
    • Thymocyte-expressed molecule involved in selection antibody
    • TSEPA antibody
    see all

Images

  • Immunohistochemical analysis of formalin-fixed and paraffin-embedded Human kidney tissue labeling Themis with ab217017 at 1/400 dilution, followed by conjugation to the secondary antibody and DAB staining.

  • Immunohistochemical analysis of formalin-fixed and paraffin-embedded Human kidney tissue labeling Themis with ab217017 at 1/400 dilution, followed by conjugation to the secondary antibody and DAB staining.

References

ab217017 has not yet been referenced specifically in any publications.

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