Overview

  • Product name
    Anti-Themis antibody - N-terminal
    See all Themis primary antibodies
  • Description
    Rabbit polyclonal to Themis - N-terminal
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse, Human
    Predicted to work with: Rat
  • Immunogen

    Synthetic peptide (Human) corresponding to a sequence from the N-terminal region of Human Themis.

  • Positive control
    • Mouse spleen tissue lysate; K562 cell lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab157811 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000. Detects a band of approximately 72 kDa (predicted molecular weight: 73 kDa).

Target

  • Function
    Plays a central role in late thymocyte development by controlling both positive and negative T-cell selection. Required to sustain and/or integrate signals required for proper lineage commitment and maturation of T-cells. Regulates T-cell development through T-cell antigen receptor (TCR) signaling and in particular through the regulation of calcium influx and phosphorylation of Erk.
  • Sequence similarities
    Belongs to the themis family.
  • Post-translational
    modifications
    Phosphorylated on Tyr residues quickly after TCR stimulation.
  • Cellular localization
    Cytoplasm. Nucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • C6orf190 antibody
    • C6orf207 antibody
    • MGC163388 antibody
    • Protein THEMIS antibody
    • SIGNALING PHOSPHOPROTEIN SPECIFIC FOR T CELLS antibody
    • SPOT antibody
    • THEMIS antibody
    • THMS1_HUMAN antibody
    • Thymocyte expressed molecule involved in selection antibody
    • Thymocyte selection associated antibody
    • Thymocyte selection pathway associated antibody
    • Thymocyte-expressed molecule involved in selection antibody
    • TSEPA antibody
    see all

Images

  • Lanes 1 & 5 : Anti-Themis antibody - N-terminal (ab157811) at 1/2000 dilution
    Lanes 2 & 6 : Anti-Themis antibody - N-terminal (ab157811) at 1/1000 dilution
    Lanes 3-4 & 7-8 : Anti-Themis antibody - N-terminal (ab157811) at 1/500 dilution

    Lanes 1-3 : Mouse spleen tissue lysate
    Lane 4 : Mouse spleen tissue lysate with blocking peptide
    Lanes 5-7 : K562 cell lysate
    Lane 8 : K562 cell lysate with blocking peptide

    Predicted band size: 73 kDa

References

ab157811 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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