Overview

  • Product name

    Thiamine hydrochloride, vitamin cofactor
  • Description

    Vitamin cofactor
  • Biological description

    Vitamin cofactor. Enables cellular oxidation of carbohydrates and synthesis of ribose. Shows neuroprotective and hepatoprotective effects in vivo. Orally active.
  • Purity

    > 99%
  • CAS Number

    67-03-8
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    2-[3-[(4-Amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-1,3-thiazol-3-ium-5-yl]ethanol chloride hydrochloride
  • Molecular weight

    337.27
  • Molecular formula

    C12H18Cl2N4OS
  • PubChem identifier

    6202
  • Storage instructions

    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water to 100 mM and in ethanol to 25 mM and in DMSO
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC1=C(SC=[N+]1CC2=CN=C(N=C2N)C)CCO.Cl.[Cl-]
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Portari GV  et al. Liver, plasma and erythrocyte levels of thiamine and its phosphate esters in rats with acute ethanol intoxication: a comparison of thiamine and benfotiamine administration. Eur J Pharm Sci 48:799-802 (2013). Read more (PubMed: 23369791) »
  • Kobayashi T  et al. Fursultiamine, a vitamin B1 derivative, enhances chondroprotective effects of glucosamine hydrochloride and chondroitin sulfate in rabbit experimental osteoarthritis. Inflamm Res 54:249-55 (2005). Read more (PubMed: 15973508) »
  • Lai F  et al. Phospholipid vesicles as carriers in aquaculture: preparation and stability study of thiamine hydrochloride-loaded liposomes. Curr Drug Deliv 1:145-52 (2004). Read more (PubMed: 16305380) »

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