Thioflavin T, Fluorescent cell-permeable amyloid binding benzothiazole salt (ab120751)
- Datasheet
- References (6)
Overview
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Product name
Thioflavin T, Fluorescent cell-permeable amyloid binding benzothiazole salt -
Description
Fluorescent cell-permeable amyloid binding benzothiazole salt -
Biological description
Fluorescent cell-permeable amyloid binding benzothiazole salt. Dye used to visualise stacked β sheets in vitro and in vivo. Binding induces a shift in excitation maximum (385 nm to 450 nm) and emission maximum (445 nm to 482 nm). Highly soluble in water. Limited ability to cross the blood-brain barrier. -
Purity
> 97% -
CAS Number
2390-54-7 -
Chemical structure
Properties
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Chemical name
4-(3,6-Dimethyl-1,3-benzothiazol-3-ium-2-yl)-N,N-dimethylaniline chloride -
Molecular weight
318.86 -
Molecular formula
C17H19ClN2S -
Storage instructions
Store at Room Temperature. The product can be stored for up to 12 months. -
Solubility overview
Soluble in water to 25mM and in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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Source
Synthetic
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Research areas
References
This product has been referenced in:
- Biancalana M & Koide S Molecular mechanism of Thioflavin-T binding to amyloid fibrils. Biochim Biophys Acta 1804:1405-12 (2010). Read more (PubMed: 20399286) »
- Darghal N et al. Mechanism of thioflavin T accumulation inside cells overexpressing P-glycoprotein or multidrug resistance-associated protein: role of lipophilicity and positive charge. Biochem Biophys Res Commun 343:623-9 (2006). Read more (PubMed: 16554036) »
