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Thioflavin T, Fluorescent cell-permeable amyloid binding benzothiazole salt (ab120751)

  • Datasheet
  • SDS
  • COA
Submit a review Q&A (1)References (15)

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Chemical Structure - Thioflavin T, Fluorescent cell-permeable amyloid binding benzothiazole salt (ab120751)

    Key features and details

    • Fluorescent cell-permeable amyloid binding benzothiazole salt
    • CAS Number: 2390-54-7
    • Purity: > 97%
    • Soluble in water to 25mM and in DMSO to 100 mM
    • Form / State: Solid
    • Source: Synthetic

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    Overview

    • Product name

      Thioflavin T, Fluorescent cell-permeable amyloid binding benzothiazole salt
    • Description

      Fluorescent cell-permeable amyloid binding benzothiazole salt
    • Biological description

      Fluorescent cell-permeable amyloid binding benzothiazole salt. Dye used to visualise stacked β sheets in vitro and in vivo. Binding induces a shift in excitation maximum (385 nm to 450 nm) and emission maximum (445 nm to 482 nm). Highly soluble in water. Limited ability to cross the blood-brain barrier.

    • Purity

      > 97%
    • CAS Number

      2390-54-7
    • Chemical structure

      Chemical Structure

    Properties

    • Chemical name

      4-(3,6-Dimethyl-1,3-benzothiazol-3-ium-2-yl)-N,N-dimethylaniline chloride
    • Molecular weight

      318.86
    • Molecular formula

      C17H19ClN2S
    • PubChem identifier

      16953
    • Storage instructions

      Store at Room Temperature. The product can be stored for up to 12 months.
    • Solubility overview

      Soluble in water to 25mM and in DMSO to 100 mM
    • Handling

      Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

      Refer to SDS for further information

      Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

    • SMILES

      CC1=CC2=C(C=C1)[N+](=C(S2)C3=CC=C(C=C3)N(C)C)C.[Cl-]
    • Source

      Synthetic

    • Research areas

      • Biochemicals
      • Product Range
      • Just Add Water
      • Biochemicals
      • Chemical Type
      • Biochemicals
      • Biochemicals
      • Chemical Type
      • Fluorescent tools
      • Biochemicals
      • Pharmacology
      • Signaling
      • Amyloidogenesis
      • Biochemicals
      • Research Area
      • Heart disease
      • Signaling
      • Amyloidogenesis
      • Biochemicals
      • Research Area
      • Pain & inflammation
      • Signaling
      • Amyloidogenesis
      • Biochemicals
      • Research Area
      • Alzheimer's Disease
      • Signaling
      • Amyloidogenesis
      • Biochemicals
      • Research Area
      • Diabetes
      • Signaling
      • Amyloidogenesis
      • Biochemicals
      • Research Area
      • Hypertension
      • Signaling
      • Amyloidogenesis
      • Biochemicals
      • Research Area
      • Obesity
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      • Amyloidogenesis
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      • Respiratory disease
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    Images

    • Chemical Structure - Thioflavin T, Fluorescent cell-permeable amyloid binding benzothiazole salt (ab120751)
      Chemical Structure - Thioflavin T, Fluorescent cell-permeable amyloid binding benzothiazole salt (ab120751)
      2D chemical structure image of ab120751, Thioflavin T, Fluorescent cell-permeable amyloid binding benzothiazole salt

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    Datasheets and documents

    • SDS download

    • Datasheet download

      Download
    • COA

    References (15)

    Publishing research using ab120751? Please let us know so that we can cite the reference in this datasheet.

    ab120751 has been referenced in 15 publications.

    • Peng CC  et al. Nifedipine Upregulates ATF6-a, Caspases -12, -3, and -7 Implicating Lipotoxicity-Associated Renal ER Stress. Int J Mol Sci 21:N/A (2020). PubMed: 32365658
    • Monaco A  et al. The Amyloid Inhibitor CLR01 Relieves Autophagy and Ameliorates Neuropathology in a Severe Lysosomal Storage Disease. Mol Ther 28:1167-1176 (2020). PubMed: 32087148
    • Sears JC & Broadie K FMRP-PKA Activity Negative Feedback Regulates RNA Binding-Dependent Fibrillation in Brain Learning and Memory Circuitry. Cell Rep 33:108266 (2020). PubMed: 33053340
    • Stephens AD  et al. Isolation and Imaging of His- and RFP-tagged Amyloid-like Proteins from Caenorhabditis elegans by TEM and SIM. Bio Protoc 9:e3408 (2019). PubMed: 33654909
    • Blancas-Mejia LM  et al. Assays for Light Chain Amyloidosis Formation and Cytotoxicity. Methods Mol Biol 1873:123-153 (2019). PubMed: 30341607
    View all Publications for this product

    Customer reviews and Q&As

    Show All Reviews Q&A
    Submit a review Submit a question

    Question

    Can Thioflavin T be used on frozen tissue?

    Read More

    Abcam community

    Verified customer

    Asked on Apr 05 2013

    Answer

    Thioflavin T has widely been used in frozen tissue so this product should work in frozen tissue.

    Read More

    Abcam Scientific Support

    Answered on Apr 05 2013

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