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    thiolutin-antibiotic-agent-ab143556.pdf

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Thiolutin, antibiotic agent (ab143556)

  • Datasheet
  • SDS
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Chemical Structure - Thiolutin, antibiotic agent (ab143556)

    Key features and details

    • Sulfur-based antibiotic agent. Potent RNA polmerase inhibitor
    • CAS Number: 87-11-6
    • Purity: > 98%
    • Soluble in DMSO to 10 mM
    • Form / State: Solid
    • Source: Synthetic

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    Overview

    • Product name

      Thiolutin, antibiotic agent
    • Description

      Sulfur-based antibiotic agent. Potent RNA polmerase inhibitor
    • Biological description

      Sulfur-based antibiotic agent. Potent RNA polymerase inhibitor. Inhibits endothelial cell adhesion (IC50 = 0.83 μM). Suppresses tumor cell induced angiogenesis and shows antitumor effects in vivo.
    • Purity

      > 98%
    • CAS Number

      87-11-6
    • Chemical structure

      Chemical Structure

    Properties

    • Chemical name

      N-(4,5-Dihydro-4-methyl-5-oxo-1,2-dithiolo[4,3-b]pyrrol-6-yl)-acetamide
    • Molecular weight

      228.29
    • Molecular formula

      C8H8N2O2S2
    • PubChem identifier

      6870
    • Storage instructions

      Store at +4°C. The product can be stored for up to 12 months.
    • Solubility overview

      Soluble in DMSO to 10 mM
    • Handling

      Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

      Toxic, refer to SDS for further information.

      Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

    • SMILES

      CC(=O)NC1=C2C(=CSS2)N(C1=O)C
    • Source

      Synthetic

    • Research areas

      • Signal Transduction
      • Growth Factors/Hormones
      • Hormones
      • Epigenetics and Nuclear Signaling
      • Nuclear Signaling Pathways
      • Nuclear Receptors
      • Corticoid
      • Epigenetics and Nuclear Signaling
      • Transcription
      • Transcription Factors
      • Biochemicals
      • Chemical Type
      • Biochemicals
      • Biochemicals
      • Chemical Type
      • Antibiotic
      • Biochemicals
      • Pharmacology
      • Signaling
      • DNA, RNA & protein synthesis
      • Polymerase and transcriptase
      • Biochemicals
      • Pharmacology
      • Signaling
      • Immunomodulators
      • Antibacterial
      • Biochemicals
      • Pharmacology
      • Enzymes
      • Polymerase & Transcriptase
      • RNA polymerase
      • Neuroscience
      • Development
      • Neuroscience
      • Processes

    Images

    • Chemical Structure - Thiolutin, antibiotic agent (ab143556)
      Chemical Structure - Thiolutin, antibiotic agent (ab143556)
      2D chemical structure image of ab143556, Thiolutin, antibiotic agent

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    Datasheets and documents

    • SDS download

    • Datasheet download

      Download

    References (4)

    Publishing research using ab143556? Please let us know so that we can cite the reference in this datasheet.

    ab143556 has been referenced in 4 publications.

    • Vasianovich Y  et al. Telomerase biogenesis requires a novel Mex67 function and a cytoplasmic association with the Sm7 complex. Elife 9:N/A (2020). PubMed: 33095156
    • Meriem ZB  et al. Hyperosmotic Stress Response Memory is Modulated by Gene Positioning in Yeast. Cells 8:N/A (2019). PubMed: 31200564
    • Dronamraju R  et al. Spt6 Association with RNA Polymerase II Directs mRNA Turnover During Transcription. Mol Cell 70:1054-1066.e4 (2018). PubMed: 29932900
    • Baptista T  et al. SAGA Is a General Cofactor for RNA Polymerase II Transcription. Mol Cell 68:130-143.e5 (2017). PubMed: 28918903

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