Overview

  • Product name

    Thiolutin, antibiotic agent
  • Description

    Sulfur-based antibiotic agent. Potent RNA polmerase inhibitor
  • Biological description

    Sulfur-based antibiotic agent. Potent RNA polymerase inhibitor. Inhibits endothelial cell adhesion (IC50 = 0.83 μM). Suppresses tumor cell induced angiogenesis and shows antitumor effects in vivo.
  • Purity

    > 98%
  • CAS Number

    87-11-6
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Jia Y  et al. Thiolutin inhibits endothelial cell adhesion by perturbing Hsp27 interactions with components of the actin and intermediate filament cytoskeleton. Cell Stress Chaperones 15:165-81 (2010). Read more (PubMed: 19579057) »
  • Minamiguchi K  et al. Thiolutin, an inhibitor of HUVEC adhesion to vitronectin, reduces paxillin in HUVECs and suppresses tumor cell-induced angiogenesis. Int J Cancer 93:307-16 (2001). Read more (PubMed: 11433393) »
  • Mehta RG & Moon RC Characterization of effective chemopreventive agents in mammary gland in vitro using an initiation-promotion protocol. Anticancer Res 11:593-6 (0). Read more (PubMed: 1905902) »
See 1 Publication for this product

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