Key features and details
- Rabbit polyclonal to Thioredoxin 2
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
Product nameAnti-Thioredoxin 2 antibody
See all Thioredoxin 2 primary antibodies
DescriptionRabbit polyclonal to Thioredoxin 2
Tested applicationsSuitable for: IHC-Pmore details
Species reactivityReacts with: Human
Recombinant full length protein corresponding to Human Thioredoxin 2 aa 1-166.
MAQRLLLRRFLASVISRKPSQGQWPPLTSRALQTPQCSPGGLTVTPNPAR TIYTTRISLTTFNIQDGPDFQDRVVNSETPVVVDFHAQWCGPCKILGPRL EKMVAKQHGKVVMAKVDIDDHTDLAIEYEVSAVPTVLAMKNGDVVDKFVG IKDEDQLEAFLKKLIG
Database link: Q99757
- IHC-P: Human tonsil, colon and pancreatic tissues.
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferpH: 7.30
Preservative: 0.02% Sodium azide
Constituents: PBS, 50% Glycerol
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab236298 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IHC-P||1/20 - 1/200.|
RelevanceThioredoxins (Trx) are small, multi-functional proteins with oxidoreductase activity and are ubiquitous in essentially all living cells. Trx contains a redox-active disulfide/dithiol group within the conserved Cys-Gly-Pro-Cys active site. The two cysteine residues in the conserved active centers can be oxidized to form intramolecular disulfide bonds. Reduction of the active site disulfide in oxidized Trx is catalyzed by Trx reductase with NADPH as the electron donor. The reduced Trx is a hydrogen donor for ribonucleotide reductase, the essential enzyme for DNA synthesis, and a potent general protein disulfide reductase with numerous functions in growth and redox regulations. Specific protein disulfide targets for reduction by Trx include protein disulfide isomerase(PDI) and a number of transcription factors such as p53, NF-kB and AP-1. Trx is also capable of removing H2O2, particularly when it is coupled with either methionine sulfoxide reductase or several isoforms of peroxiredoxins.
- mitochondrial thioredoxin antibody
- MT-TRX antibody
- MTRX antibody
Paraffin-embedded human tonsil tissue stained for Thioredoxin 2 using ab236298 at 1/100 dilution in immunohistochemical analysis.
Paraffin-embedded human colon tissue stained for Thioredoxin 2 using ab236298 at 1/100 dilution in immunohistochemical analysis.
Paraffin-embedded human pancreatic tissue stained for Thioredoxin 2 using ab236298 at 1/100 dilution in immunohistochemical analysis.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab236298 has not yet been referenced specifically in any publications.