Overview

  • Product name

    Thiostrepton, Protein synthesis inhibitor
  • Description

    Potent Gram-positive antibiotic. Protein synthesis inhibitor.
  • Biological description

    Potent Gram-positive antibiotic. Protein synthesis inhibitor. Inhibits FOXM1. Shows antitumor effects in vivo. Enhances cisplatin (Asc 1398) activity.
  • Purity

    > 97%
  • CAS Number

    1393-48-2
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    8-Dihydro-8-hydroxy-4-(1-hydroxyethyl)-7-quinolinyl]isoleucylalanyl-2,3-didehydroalanylalanyl-2-[4a-amino-21-(1,2-dihydroxy-1-methylpropyl)-14-ethylidene-3,4,4a,9,10,11,12,13,14,18,19,20,21,27,28,32a-hexadecahydro-11,28-bis(1-hydroxyethyl)-9,12,19,26-tetraoxo-17H,26H-8,5:18,15:25,22:32,29-tetranitrilo-5H,15H-pyrido[3,2-m][1,11,17,24,4,7,20,27]tetrathiatetraazacyclotriacontin-2-yl]-4-thiazolecarbonyl-2,3-didehydroalanyl-2,3-didehydro-alaninamide
  • Molecular weight

    1664.89
  • Molecular formula

    C72H85N19O18S5
  • PubChem identifier

    16220061
  • Storage instructions

    Store at +4°C. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 10 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CCC(C)C1C(=O)NC(C(=O)NC(=C)C(=O)NC(C(=O)NC23CCC(=NC2C4=CSC(=N4)C(C(OC(=O)C5=NC6=C(C=CC(C6O)N1)C(=C5)C(C)O)C)NC(=O)C7=CSC(=N7)C(NC(=O)C8CSC(=N8)C(=CC)NC(=O)C(NC(=O)C9=CSC3=N9)C(C)O)C(C)(C(C)O)O)C1=NC(=CS1)C(=O)NC(=C) C(=O)NC(=C)C(=O)N)C)C
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Sengupta A  et al. The dual inhibitory effect of thiostrepton on FoxM1 and EWS/FLI1 provides a novel therapeutic option for Ewing's sarcoma. Int J Oncol 43:803-12 (2013). Read more (PubMed: 23857410) »
  • Lin J  et al. Inhibition of FOXM1 by thiostrepton sensitizes medulloblastoma to the effects of chemotherapy. Oncol Rep 30:1739-44 (2013). Read more (PubMed: 23912794) »
  • Uchiumi T  et al. A base substitution within the GTPase-associated domain of mammalian 28 S ribosomal RNA causes high thiostrepton accessibility. J Biol Chem 270:29889-93 (1995). Read more (PubMed: 8530386) »
See 1 Publication for this product

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