Product nameAnti-Thrombin antibody (Biotin)
See all Thrombin primary antibodies
DescriptionRabbit polyclonal to Thrombin (Biotin)
Tested applicationsSuitable for: RIA, ELISA, IP, WBmore details
Species reactivityReacts with: Human
Full length native protein from plasma (purified) (Human)
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.
Storage bufferpH: 7.50
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: PBS, 50% Glycerol
Concentration information loading...
PurityProtein G purified
Our Abpromise guarantee covers the use of ab49552 in the following tested applications.
|RIA||Use at an assay dependent dilution.|
|ELISA||Use at an assay dependent dilution.|
|IP||Use at an assay dependent dilution.|
|WB||Use at an assay dependent dilution. Predicted molecular weight: 70 kDa.|
FunctionThrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing.
Tissue specificityExpressed by the liver and secreted in plasma.
Involvement in diseaseFactor II deficiency
Thrombophilia due to thrombin defect
Pregnancy loss, recurrent, 2
Sequence similaritiesBelongs to the peptidase S1 family.
Contains 1 Gla (gamma-carboxy-glutamate) domain.
Contains 2 kringle domains.
Contains 1 peptidase S1 domain.
modificationsThe gamma-carboxyglutamyl residues, which bind calcium ions, result from the carboxylation of glutamyl residues by a microsomal enzyme, the vitamin K-dependent carboxylase. The modified residues are necessary for the calcium-dependent interaction with a negatively charged phospholipid surface, which is essential for the conversion of prothrombin to thrombin.
N-glycosylated. N-glycan heterogeneity at Asn-121: Hex3HexNAc3 (minor), Hex4HexNAc3 (minor) and Hex5HexNAc4 (major). At Asn-143: Hex4HexNAc3 (minor) and Hex5HexNAc4 (major).
Cellular localizationSecreted, extracellular space.
- Information by UniProt
- Coagulation factor II antibody
- Coagulation factor II thrombin antibody
- EC 220.127.116.11 antibody
ab49552 has not yet been referenced specifically in any publications.