Overview

  • Product name

    Anti-Thromboxane A2 receptor/TBXA2R antibody
    See all Thromboxane A2 receptor/TBXA2R primary antibodies
  • Description

    Rabbit polyclonal to Thromboxane A2 receptor/TBXA2R
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Synthetic peptide corresponding to Human Thromboxane A2 receptor/TBXA2R aa 1-45 (N terminal).
    Sequence:

    MWPNGSSLGPCFRPTNITLEERRLIASPWFAASFCVVGLASNLLA

  • Positive control

    • Raji whole cell lysate; HeLaS3 and HepG2 cell lysate
  • General notes

     This product was previously labelled as Thromboxane A2 receptor

     

Properties

Applications

Our Abpromise guarantee covers the use of ab137607 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 37 kDa.

Target

  • Function

    Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. In the kidney, the binding of TXA2 to glomerular TP receptors causes intense vasoconstriction. Activates phospholipase C. Isoform 1 activates adenylyl cyclase. Isoform 2 inhibits adenylyl cyclase.
  • Involvement in disease

    Defects in TBXA2R are the cause of susceptibility to bleeding disorder platelet-type 13 (BDPLT13) [MIM:614009]. BDPLT13 is a disorder characterized by reduced platelet aggregation and a tendency to mild mucocutaneous bleeding.
  • Sequence similarities

    Belongs to the G-protein coupled receptor 1 family.
  • Cellular localization

    Cell membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • BDPLT13 antibody
    • Prostanoid TP receptor antibody
    • TA2R_HUMAN antibody
    • Tbxa2r antibody
    • Thromboxane A2 receptor antibody
    • TP receptor antibody
    • TXA2 R antibody
    • TXA2-R antibody
    • TXA2R antibody
    see all

Images

  • Anti-Thromboxane A2 receptor/TBXA2R antibody (ab137607) at 1/500 dilution + Raji whole cell lysate at 30 µg

    Predicted band size: 37 kDa



    12% SDS PAGE

References

ab137607 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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