Key features and details
- Rabbit polyclonal to Thromboxane A2 receptor/TBXA2R
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Product nameAnti-Thromboxane A2 receptor/TBXA2R antibody
See all Thromboxane A2 receptor/TBXA2R primary antibodies
DescriptionRabbit polyclonal to Thromboxane A2 receptor/TBXA2R
Tested applicationsSuitable for: WBmore details
Species reactivityReacts with: Human
- Raji whole cell lysate; HeLaS3 and HepG2 cell lysate
This product was previously labelled as Thromboxane A2 receptor
Storage instructionsShipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
Storage bufferpH: 7.00
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 1.21% Tris, 0.75% Glycine, 20% Glycerol
Concentration information loading...
PurityImmunogen affinity purified
- Pathways and Processes
- Metabolic signaling pathways
- Lipid and lipoprotein metabolism
- Lipoprotein metabolism
Our Abpromise guarantee covers the use of ab137607 in the following tested applications.
|WB||1/500 - 1/3000. Predicted molecular weight: 37 kDa.|
FunctionReceptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. In the kidney, the binding of TXA2 to glomerular TP receptors causes intense vasoconstriction. Activates phospholipase C. Isoform 1 activates adenylyl cyclase. Isoform 2 inhibits adenylyl cyclase.
Involvement in diseaseDefects in TBXA2R are the cause of susceptibility to bleeding disorder platelet-type 13 (BDPLT13) [MIM:614009]. BDPLT13 is a disorder characterized by reduced platelet aggregation and a tendency to mild mucocutaneous bleeding.
Sequence similaritiesBelongs to the G-protein coupled receptor 1 family.
Cellular localizationCell membrane.
- Information by UniProt
- BDPLT13 antibody
- Prostanoid TP receptor antibody
- TA2R_HUMAN antibody
ab137607 has been referenced in 1 publication.
- Song W et al. Edoxaban improves venous thrombosis via increasing hydrogen sulfide and homocysteine in rat model. Mol Med Rep 16:7706-7714 (2017). PubMed: 28944880