Key features and details
- Rabbit polyclonal to Thromboxane A2 receptor/TBXA2R - Cytoplasm Marker
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
Product nameAnti-Thromboxane A2 receptor/TBXA2R antibody - Cytoplasm Marker
See all Thromboxane A2 receptor/TBXA2R primary antibodies
DescriptionRabbit polyclonal to Thromboxane A2 receptor/TBXA2R - Cytoplasm Marker
SpecificityBLAST analysis of the peptide immunogen showed no homology with other Human proteins.
Tested applicationsSuitable for: IHC-Pmore details
Species reactivityReacts with: Human
Predicted to work with: Cow, Dog, Pig, Monkey, Gorilla, Common marmoset, Bat, Elephant
Synthetic peptide within Human Thromboxane A2 receptor/TBXA2R. The exact sequence is proprietary. Third cytoplasmic domain. 20 amino acid peptide.
Database link: P21731
- Human uterus, endometrium tissue.
This product was previously labelled as Thromboxane A2 receptor
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferPreservative: 0.1% Sodium azide
Constituent: 99% PBS
Concentration information loading...
PurityImmunogen affinity purified
- Pathways and Processes
- Metabolic signaling pathways
- Lipid and lipoprotein metabolism
- Lipoprotein metabolism
Our Abpromise guarantee covers the use of ab188897 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IF||Use at an assay dependent concentration.|
|IHC-P||Use a concentration of 4 µg/ml. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.|
FunctionReceptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. In the kidney, the binding of TXA2 to glomerular TP receptors causes intense vasoconstriction. Activates phospholipase C. Isoform 1 activates adenylyl cyclase. Isoform 2 inhibits adenylyl cyclase.
Involvement in diseaseDefects in TBXA2R are the cause of susceptibility to bleeding disorder platelet-type 13 (BDPLT13) [MIM:614009]. BDPLT13 is a disorder characterized by reduced platelet aggregation and a tendency to mild mucocutaneous bleeding.
Sequence similaritiesBelongs to the G-protein coupled receptor 1 family.
Cellular localizationCell membrane.
- Information by UniProt
- BDPLT13 antibody
- Prostanoid TP receptor antibody
- TA2R_HUMAN antibody
ab188897 has been referenced in 1 publication.
- Ahmad AA et al. Sex differences in the role of phospholipase A2 -dependent arachidonic acid pathway in the perivascular adipose tissue function in pigs. J Physiol 595:6623-6634 (2017). PubMed: 28877347