Product nameAnti-Thromboxane A2 receptor/TBXA2R antibody [EPR7336]
See all Thromboxane A2 receptor/TBXA2R primary antibodies
DescriptionRabbit monoclonal [EPR7336] to Thromboxane A2 receptor/TBXA2R
Tested applicationsSuitable for: WBmore details
Unsuitable for: IHC-P or IP
Species reactivityReacts with: Mouse, Rat, Human
corresponding to Human Thromboxane A2 receptor/TBXA2R aa 300-400.
- Human platelet, fetal kidney and fetal heart lysates.
This product was previously labelled as Thromboxane A2 receptor
This product is a recombinant monoclonal antibody, which offers several advantages including:
- - High batch-to-batch consistency and reproducibility
- - Improved sensitivity and specificity
- - Long-term security of supply
- - Animal-free production
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
Storage instructionsShipped at 4°C. Store at -20ºC.
Storage bufferpH: 7.20
Preservative: 0.01% Sodium azide
Constituents: 9% PBS, 40% Glycerol, 0.05% BSA, 50% Tissue culture supernatant
Concentration information loading...
PurityTissue culture supernatant
- Pathways and Processes
- Metabolic signaling pathways
- Lipid and lipoprotein metabolism
- Lipoprotein metabolism
Our Abpromise guarantee covers the use of ab134959 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/1000 - 1/10000. Predicted molecular weight: 37 kDa.|
FunctionReceptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. In the kidney, the binding of TXA2 to glomerular TP receptors causes intense vasoconstriction. Activates phospholipase C. Isoform 1 activates adenylyl cyclase. Isoform 2 inhibits adenylyl cyclase.
Involvement in diseaseDefects in TBXA2R are the cause of susceptibility to bleeding disorder platelet-type 13 (BDPLT13) [MIM:614009]. BDPLT13 is a disorder characterized by reduced platelet aggregation and a tendency to mild mucocutaneous bleeding.
Sequence similaritiesBelongs to the G-protein coupled receptor 1 family.
Cellular localizationCell membrane.
- Information by UniProt
- BDPLT13 antibody
- Prostanoid TP receptor antibody
- TA2R_HUMAN antibody
All lanes : Anti-Thromboxane A2 receptor/TBXA2R antibody [EPR7336] (ab134959) at 1/1000 dilution
Lane 1 : Human platelet lysate
Lane 2 : Human fetal kidney lysate
Lane 3 : Human fetal heart lysate
Lysates/proteins at 10 µg per lane.
All lanes : HRP labelled goat anti rabbit at 10 µg
Predicted band size: 37 kDa
This product has been referenced in:
- Wang P et al. Inflammatory mediators mediate airway smooth muscle contraction through a G protein-coupled receptor-transmembrane protein 16A-voltage-dependent Ca2+ channel axis and contribute to bronchial hyperresponsiveness in asthma. J Allergy Clin Immunol 141:1259-1268.e11 (2018). WB . Read more (PubMed: 28754608) »