Anti-Thromboxane A2 receptor/TBXA2R antibody - Membrane Vesicle Marker (ab222315)
Key features and details
- Rabbit polyclonal to Thromboxane A2 receptor/TBXA2R - Membrane Vesicle Marker
- Suitable for: ICC/IF
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-Thromboxane A2 receptor/TBXA2R antibody - Membrane Vesicle Marker
See all Thromboxane A2 receptor/TBXA2R primary antibodies -
Description
Rabbit polyclonal to Thromboxane A2 receptor/TBXA2R - Membrane Vesicle Marker -
Host species
Rabbit -
Tested applications
Suitable for: ICC/IFmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Cow -
Immunogen
Recombinant fragment corresponding to Human Thromboxane A2 receptor/TBXA2R aa 2-29 (N terminal).
Sequence:WPNGSSLGPCFRPTNITLEERRLIASPW
Database link: P21731 -
Positive control
- ICC/IF: BJ cells.
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General notes
This product was previously labelled as Thromboxane A2 receptor
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Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.
We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.
In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
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Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.20
Preservative: 0.02% Sodium azide
Constituents: 40% Glycerol (glycerin, glycerine), PBS -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
Our Abpromise guarantee covers the use of ab222315 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
---|---|---|
ICC/IF | Use a concentration of 0.25 - 2 µg/ml. Fixation/Permeabilization: PFA/Triton X-100. |
Target
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Function
Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. In the kidney, the binding of TXA2 to glomerular TP receptors causes intense vasoconstriction. Activates phospholipase C. Isoform 1 activates adenylyl cyclase. Isoform 2 inhibits adenylyl cyclase. -
Involvement in disease
Defects in TBXA2R are the cause of susceptibility to bleeding disorder platelet-type 13 (BDPLT13) [MIM:614009]. BDPLT13 is a disorder characterized by reduced platelet aggregation and a tendency to mild mucocutaneous bleeding. -
Sequence similarities
Belongs to the G-protein coupled receptor 1 family. -
Cellular localization
Cell membrane. - Information by UniProt
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Database links
- Entrez Gene: 538783 Cow
- Entrez Gene: 6915 Human
- Omim: 188070 Human
- SwissProt: Q95125 Cow
- SwissProt: P21731 Human
- Unigene: 442530 Human
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Alternative names
- BDPLT13 antibody
- Prostanoid TP receptor antibody
- TA2R_HUMAN antibody
see all
Images
Protocols
Datasheets and documents
References (0)
ab222315 has not yet been referenced specifically in any publications.