Anti-Thromboxane A2 receptor/TBXA2R antibody - Membrane Vesicle Marker (ab222315)

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Overview

  • Product name

    Anti-Thromboxane A2 receptor/TBXA2R antibody - Membrane Vesicle Marker
    See all Thromboxane A2 receptor/TBXA2R primary antibodies

  • Description

    Rabbit polyclonal to Thromboxane A2 receptor/TBXA2R - Membrane Vesicle Marker

  • Host species

    Rabbit

  • Tested applications

    Suitable for: ICC/IFmore details

  • Species reactivity

    Reacts with: Human
    Predicted to work with: Cow

  • Immunogen

    Recombinant fragment corresponding to Human Thromboxane A2 receptor/TBXA2R aa 2-29 (N terminal).
    Sequence:

    WPNGSSLGPCFRPTNITLEERRLIASPW


    Database link: P21731

    Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI

  • Positive control

    • ICC/IF: BJ cells.

  • General notes

     This product was previously labelled as Thromboxane A2 receptor

     

Properties

Applications

Our Abpromise guarantee covers the use of ab222315 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF Use a concentration of 1 - 4 µg/ml.

Fixation/Permeabilization: PFA/Triton X-100.

Target

  • Function

    Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. In the kidney, the binding of TXA2 to glomerular TP receptors causes intense vasoconstriction. Activates phospholipase C. Isoform 1 activates adenylyl cyclase. Isoform 2 inhibits adenylyl cyclase.

  • Involvement in disease

    Defects in TBXA2R are the cause of susceptibility to bleeding disorder platelet-type 13 (BDPLT13) [MIM:614009]. BDPLT13 is a disorder characterized by reduced platelet aggregation and a tendency to mild mucocutaneous bleeding.

  • Sequence similarities

    Belongs to the G-protein coupled receptor 1 family.

  • Cellular localization

    Cell membrane.
  • Information by UniProt

  • Database links

    • Alternative names

      • BDPLT13 antibody
      • Prostanoid TP receptor antibody
      • TA2R_HUMAN antibody
      • Tbxa2r antibody
      • Thromboxane A2 receptor antibody
      • TP receptor antibody
      • TXA2 R antibody
      • TXA2-R antibody
      • TXA2R antibody
      see all

    Images

    • Immunocytochemistry/ Immunofluorescence - Anti-Thromboxane A2 receptor/TBXA2R antibody - Membrane Vesicle Marker (ab222315)
      Immunocytochemistry/ Immunofluorescence - Anti-Thromboxane A2 receptor/TBXA2R antibody - Membrane Vesicle Marker (ab222315)

      PFA-fixed, Triton X-100 permeabilized BJ cells stained for Thromboxane A2 receptor/TBXA2R (green) using ab222315 at 4 µg/ml in ICC/IF.

    References

    ab222315 has not yet been referenced specifically in any publications.

    Publishing research using ab222315? Please let us know so that we can cite the reference in this datasheet.

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