Anti-Thromboxane A2 receptor/TBXA2R antibody - Membrane Vesicle Marker (ab222315)

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Immunocytochemistry/ Immunofluorescence - Anti-Thromboxane A2 receptor/TBXA2R antibody - Membrane Vesicle Marker (ab222315)

    Key features and details

    • Rabbit polyclonal to Thromboxane A2 receptor/TBXA2R - Membrane Vesicle Marker
    • Suitable for: ICC/IF
    • Reacts with: Human
    • Isotype: IgG

    Overview

    • Product name

      Anti-Thromboxane A2 receptor/TBXA2R antibody - Membrane Vesicle Marker
      See all Thromboxane A2 receptor/TBXA2R primary antibodies

    • Description

      Rabbit polyclonal to Thromboxane A2 receptor/TBXA2R - Membrane Vesicle Marker

    • Host species

      Rabbit

    • Tested applications

      Suitable for: ICC/IFmore details

    • Species reactivity

      Reacts with: Human
      Predicted to work with: Cow

    • Immunogen

      Recombinant fragment corresponding to Human Thromboxane A2 receptor/TBXA2R aa 2-29 (N terminal).
      Sequence:

      WPNGSSLGPCFRPTNITLEERRLIASPW


      Database link: P21731
      Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI

    • Positive control

      • ICC/IF: BJ cells.

    • General notes

       This product was previously labelled as Thromboxane A2 receptor

       

      Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.

      Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.

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      In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.

      We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.

      Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.

      Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.

    Properties

    Applications

    Our Abpromise guarantee covers the use of ab222315 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Abreviews Notes
    ICC/IF Use a concentration of 0.25 - 2 µg/ml.

    Fixation/Permeabilization: PFA/Triton X-100.

    Target

    • Function

      Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. In the kidney, the binding of TXA2 to glomerular TP receptors causes intense vasoconstriction. Activates phospholipase C. Isoform 1 activates adenylyl cyclase. Isoform 2 inhibits adenylyl cyclase.

    • Involvement in disease

      Defects in TBXA2R are the cause of susceptibility to bleeding disorder platelet-type 13 (BDPLT13) [MIM:614009]. BDPLT13 is a disorder characterized by reduced platelet aggregation and a tendency to mild mucocutaneous bleeding.

    • Sequence similarities

      Belongs to the G-protein coupled receptor 1 family.

    • Cellular localization

      Cell membrane.
    • Information by UniProt

    • Database links

      • Alternative names

        • BDPLT13 antibody
        • Prostanoid TP receptor antibody
        • TA2R_HUMAN antibody
        • Tbxa2r antibody
        • Thromboxane A2 receptor antibody
        • TP receptor antibody
        • TXA2 R antibody
        • TXA2-R antibody
        • TXA2R antibody
        see all

      Images

      • Immunocytochemistry/ Immunofluorescence - Anti-Thromboxane A2 receptor/TBXA2R antibody - Membrane Vesicle Marker (ab222315)
        Immunocytochemistry/ Immunofluorescence - Anti-Thromboxane A2 receptor/TBXA2R antibody - Membrane Vesicle Marker (ab222315)

        PFA-fixed, Triton X-100 permeabilized BJ cells stained for Thromboxane A2 receptor/TBXA2R (green) using ab222315 at 4 µg/ml in ICC/IF.

      References (0)

      Publishing research using ab222315? Please let us know so that we can cite the reference in this datasheet.

      ab222315 has not yet been referenced specifically in any publications.

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