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RecombinantRabMAb

Recombinant Anti-Thromboxane synthase antibody [EPR7333(2)] (ab157481)

  • Datasheet
  • SDS
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Western blot - Anti-Thromboxane synthase antibody [EPR7333(2)] (ab157481)
  • Anti-Thromboxane synthase antibody [EPR7333(2)] (ab157481)

Key features and details

  • Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
  • Rabbit monoclonal [EPR7333(2)] to Thromboxane synthase
  • Suitable for: WB
  • Reacts with: Human

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Secondary
Product image
Goat Anti-Rabbit IgG H&L (HRP) (ab205718)

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Overview

  • Product name

    Anti-Thromboxane synthase antibody [EPR7333(2)]
    See all Thromboxane synthase primary antibodies
  • Description

    Rabbit monoclonal [EPR7333(2)] to Thromboxane synthase
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
    Unsuitable for: ICC,IHC-P or IP
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse
  • Immunogen

    Synthetic peptide corresponding to residues in Human Thromboxane synthase (UniProt P24557).

  • Positive control

    • WI38 and fetal liver lysates.
  • General notes

    Rat: We have preliminary internal testing data to indicate this antibody may not react with this species. Please contact us for more information.

    This product is a recombinant monoclonal antibody, which offers several advantages including:

    • - High batch-to-batch consistency and reproducibility
    • - Improved sensitivity and specificity
    • - Long-term security of supply
    • - Animal-free production
    For more information see here.

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at -20ºC.
  • Storage buffer

    pH: 7.2
    Preservative: 0.01% Sodium azide
    Constituents: 9% PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, 50% Tissue culture supernatant
  • Concentration information loading...
  • Purity

    Tissue culture supernatant
  • Clonality

    Monoclonal
  • Clone number

    EPR7333(2)
  • Isotype

    IgG
  • Research areas

    • Signal Transduction
    • Metabolism
    • Vitamins / Minerals
    • Cell Biology
    • Other Antibodies
    • Oxidative Stress
    • Cardiovascular
    • Atherosclerosis
    • Thrombosis
    • Platelets
    • Cancer
    • Cancer Metabolism
    • Metabolic signaling pathway
    • Hormone biosynthesis
    • Metabolism
    • Pathways and Processes
    • Cofactors, Vitamins / minerals
    • Vitamins / minerals
    • Metabolism
    • Pathways and Processes
    • Redox metabolism
    • Oxidative stress
    • Metabolism
    • Pathways and Processes
    • Endocrine metabolism
    • Hormone biosynthesis
    • Metabolism
    • Types of disease
    • Heart disease

Associated products

  • Alternative Versions

    • Anti-Thromboxane synthase antibody [EPR7333(2)] - BSA and Azide free (ab249344)
  • Isotype control

    • Rabbit IgG, monoclonal [EPR25A] - Isotype Control (ab172730)
  • Positive Controls

    • WI-38 whole cell lysate (ab3960)

Applications

The Abpromise guarantee

Our Abpromise guarantee covers the use of ab157481 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
1/1000 - 1/5000. Predicted molecular weight: 61 kDa.
Notes
WB
1/1000 - 1/5000. Predicted molecular weight: 61 kDa.
  • Application notes
    Is unsuitable for ICC,IHC-P or IP.
  • Target

    • Tissue specificity

      Platelets, lung, kidney, spleen, macrophages and lung fibroblasts.
    • Involvement in disease

      Defects in TBXAS1 are the cause of Ghosal hematodiaphyseal dysplasia (GHDD) [MIM:231095]. GHDD is a rare autosomal recessive disorder characterized by increased bone density with predominant diaphyseal involvement and aregenerative corticosteroid-sensitive anemia. Aregenerative anemia is characterized by bone marrow failure, so that functional marrow cells are regenerated slowly or not at all.
      Defects in TBXAS1 are the cause of thromboxane synthetase deficiency (TBXAS1 deficiency) [MIM:274180]. It is characterized by hemorrhagic diathesis.
    • Sequence similarities

      Belongs to the cytochrome P450 family.
    • Cellular localization

      Endoplasmic reticulum membrane.
    • Target information above from: UniProt accession P24557 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt
    • Database links

      • Entrez Gene: 6916 Human
      • Entrez Gene: 21391 Mouse
      • Omim: 274180 Human
      • SwissProt: P24557 Human
      • SwissProt: P36423 Mouse
      • Unigene: 520757 Human
      • Unigene: 4054 Mouse
      • Alternative names

        • BDPLT14 antibody
        • CYP5 antibody
        • CYP5A1 antibody
        • Cytochrome P450 5A1 antibody
        • Cytochrome P450, family 5, subfamily A, polypeptide 1 antibody
        • FLJ52771 antibody
        • GHOSAL antibody
        • Platelet cytochrome P450 subfamily V antibody
        • Tbxas1 antibody
        • THAS antibody
        • THAS_HUMAN antibody
        • Thromboxane A synthase 1 (platelet) antibody
        • Thromboxane A synthase 1 (platelet, cytochrome P450, family 5, subfamily A) antibody
        • Thromboxane A synthase 1 antibody
        • Thromboxane A synthase 1 platelet cytochrome P450 subfamily V antibody
        • Thromboxane-A synthase antibody
        • TS antibody
        • TXA synthase antibody
        • TXAS antibody
        • TXS antibody
        see all

      Images

      • Western blot - Anti-Thromboxane synthase antibody [EPR7333(2)] (ab157481)
        Western blot - Anti-Thromboxane synthase antibody [EPR7333(2)] (ab157481)
        All lanes : Anti-Thromboxane synthase antibody [EPR7333(2)] (ab157481) at 1/1000 dilution

        Lane 1 : WI38 cell lysate
        Lane 2 : Fetal liver lysate

        Lysates/proteins at 10 µg per lane.

        Secondary
        All lanes : HRP labelled goat anti-rabbit at 1/2000 dilution

        Predicted band size: 61 kDa

      • Anti-Thromboxane synthase antibody [EPR7333(2)] (ab157481)
        Anti-Thromboxane synthase antibody [EPR7333(2)] (ab157481)

      Protocols

      • Western blot protocols

      Click here to view the general protocols

      Datasheets and documents

      • SDS download

      • Datasheet download

        Download

      References (1)

      Publishing research using ab157481? Please let us know so that we can cite the reference in this datasheet.

      ab157481 has been referenced in 1 publication.

      • Cianciaruso C  et al. Molecular Profiling and Functional Analysis of Macrophage-Derived Tumor Extracellular Vesicles. Cell Rep 27:3062-3080.e11 (2019). PubMed: 31167148

      Customer reviews and Q&As

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