RecombinantRabMAb

Recombinant Anti-Thromboxane synthase antibody [EPR7333(2)] (ab157481)

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Western blot - Anti-Thromboxane synthase antibody [EPR7333(2)] (ab157481)
  • Anti-Thromboxane synthase antibody [EPR7333(2)] (ab157481)

Key features and details

  • Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
  • Rabbit monoclonal [EPR7333(2)] to Thromboxane synthase
  • Suitable for: WB
  • Reacts with: Human

Overview

  • Product name

    Anti-Thromboxane synthase antibody [EPR7333(2)]
    See all Thromboxane synthase primary antibodies

  • Description

    Rabbit monoclonal [EPR7333(2)] to Thromboxane synthase

  • Host species

    Rabbit

  • Tested applications

    Suitable for: WBmore details
    Unsuitable for: ICC,IHC-P or IP

  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse

  • Immunogen

    Synthetic peptide corresponding to residues in Human Thromboxane synthase (UniProt P24557).

  • Positive control

    • WI38 and fetal liver lysates.

  • General notes

    Rat: We have preliminary internal testing data to indicate this antibody may not react with this species. Please contact us for more information.

    This product is a recombinant monoclonal antibody, which offers several advantages including:

    • - High batch-to-batch consistency and reproducibility
    • - Improved sensitivity and specificity
    • - Long-term security of supply
    • - Animal-free production
    For more information see here.

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

Properties

Applications

The Abpromise guarantee

Our Abpromise guarantee covers the use of ab157481 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
1/1000 - 1/5000. Predicted molecular weight: 61 kDa.
Notes
WB
1/1000 - 1/5000. Predicted molecular weight: 61 kDa.
  • Application notes
    Is unsuitable for ICC,IHC-P or IP.

    • Target

    • Tissue specificity

      Platelets, lung, kidney, spleen, macrophages and lung fibroblasts.

    • Involvement in disease

      Defects in TBXAS1 are the cause of Ghosal hematodiaphyseal dysplasia (GHDD) [MIM:231095]. GHDD is a rare autosomal recessive disorder characterized by increased bone density with predominant diaphyseal involvement and aregenerative corticosteroid-sensitive anemia. Aregenerative anemia is characterized by bone marrow failure, so that functional marrow cells are regenerated slowly or not at all.
      Defects in TBXAS1 are the cause of thromboxane synthetase deficiency (TBXAS1 deficiency) [MIM:274180]. It is characterized by hemorrhagic diathesis.

    • Sequence similarities

      Belongs to the cytochrome P450 family.

    • Cellular localization

      Endoplasmic reticulum membrane.
    • Information by UniProt

    • Database links

      • Alternative names

        • BDPLT14 antibody
        • CYP5 antibody
        • CYP5A1 antibody
        • Cytochrome P450 5A1 antibody
        • Cytochrome P450, family 5, subfamily A, polypeptide 1 antibody
        • FLJ52771 antibody
        • GHOSAL antibody
        • Platelet cytochrome P450 subfamily V antibody
        • Tbxas1 antibody
        • THAS antibody
        • THAS_HUMAN antibody
        • Thromboxane A synthase 1 (platelet) antibody
        • Thromboxane A synthase 1 (platelet, cytochrome P450, family 5, subfamily A) antibody
        • Thromboxane A synthase 1 antibody
        • Thromboxane A synthase 1 platelet cytochrome P450 subfamily V antibody
        • Thromboxane-A synthase antibody
        • TS antibody
        • TXA synthase antibody
        • TXAS antibody
        • TXS antibody
        see all

      Images

      • Western blot - Anti-Thromboxane synthase antibody [EPR7333(2)] (ab157481)
        Western blot - Anti-Thromboxane synthase antibody [EPR7333(2)] (ab157481)
        All lanes : Anti-Thromboxane synthase antibody [EPR7333(2)] (ab157481) at 1/1000 dilution

        Lane 1 : WI38 cell lysate
        Lane 2 : Fetal liver lysate

        Lysates/proteins at 10 µg per lane.

        Secondary
        All lanes : HRP labelled goat anti-rabbit at 1/2000 dilution

        Predicted band size: 61 kDa

      • Anti-Thromboxane synthase antibody [EPR7333(2)] (ab157481)
        Anti-Thromboxane synthase antibody [EPR7333(2)] (ab157481)

      References (1)

      Publishing research using ab157481? Please let us know so that we can cite the reference in this datasheet.

      ab157481 has been referenced in 1 publication.

      • Cianciaruso C  et al. Molecular Profiling and Functional Analysis of Macrophage-Derived Tumor Extracellular Vesicles. Cell Rep 27:3062-3080.e11 (2019). PubMed: 31167148

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