Recombinant Anti-Thromboxane synthase antibody [EPR7333(2)] (ab157481)
Overview
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Product name
Anti-Thromboxane synthase antibody [EPR7333(2)]
See all Thromboxane synthase primary antibodies -
Description
Rabbit monoclonal [EPR7333(2)] to Thromboxane synthase -
Host species
Rabbit -
Tested applications
Suitable for: WBmore details
Unsuitable for: ICC,IHC-P or IP -
Species reactivity
Reacts with: Mouse, Human -
Immunogen
Synthetic peptide corresponding to residues in Human Thromboxane synthase (UniProt P24557).
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Positive control
- WI38 and fetal liver lysates.
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General notes
Rat: We have preliminary internal testing data to indicate this antibody may not react with this species. Please contact us for more information.
This product is a recombinant monoclonal antibody, which offers several advantages including:
- - High batch-to-batch consistency and reproducibility
- - Improved sensitivity and specificity
- - Long-term security of supply
- - Animal-free production
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at -20ºC. -
Storage buffer
Preservative: 0.01% Sodium azide
Constituents: 9% PBS, 40% Glycerol, 0.05% BSA, 50% Tissue culture supernatant -
Concentration information loading... -
Purity
Tissue culture supernatant -
Clonality
Monoclonal -
Clone number
EPR7333(2) -
Isotype
IgG -
Research areas
Associated products
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Alternative Versions
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Isotype control
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Positive Controls
Applications
Our Abpromise guarantee covers the use of ab157481 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| WB | 1/1000 - 1/5000. Predicted molecular weight: 61 kDa. |
Target
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Tissue specificity
Platelets, lung, kidney, spleen, macrophages and lung fibroblasts. -
Involvement in disease
Defects in TBXAS1 are the cause of Ghosal hematodiaphyseal dysplasia (GHDD) [MIM:231095]. GHDD is a rare autosomal recessive disorder characterized by increased bone density with predominant diaphyseal involvement and aregenerative corticosteroid-sensitive anemia. Aregenerative anemia is characterized by bone marrow failure, so that functional marrow cells are regenerated slowly or not at all.
Defects in TBXAS1 are the cause of thromboxane synthetase deficiency (TBXAS1 deficiency) [MIM:274180]. It is characterized by hemorrhagic diathesis. -
Sequence similarities
Belongs to the cytochrome P450 family. -
Cellular localization
Endoplasmic reticulum membrane. - Information by UniProt
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Database links
- Entrez Gene: 6916 Human
- Entrez Gene: 21391 Mouse
- Omim: 274180 Human
- SwissProt: P24557 Human
- SwissProt: P36423 Mouse
- Unigene: 520757 Human
- Unigene: 4054 Mouse
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Alternative names
- BDPLT14 antibody
- CYP5 antibody
- CYP5A1 antibody
see all
Images
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![Western blot - Anti-Thromboxane synthase antibody [EPR7333(2)] (ab157481)](https://www.abcam.com/ps/products/157/ab157481/Images/ab157481-164558-anti-thromboxane-synthase-antibody-epr73332-western-blot.jpg)
Western blot - Anti-Thromboxane synthase antibody [EPR7333(2)] (ab157481)All lanes : Anti-Thromboxane synthase antibody [EPR7333(2)] (ab157481) at 1/1000 dilution
Lane 1 : WI38 cell lysate
Lane 2 : Fetal liver lysate
Lysates/proteins at 10 µg per lane.
Secondary
All lanes : HRP labelled goat anti-rabbit at 1/2000 dilution
Predicted band size: 61 kDa
Datasheets and documents
References
ab157481 has been referenced in 1 publication.
- Cianciaruso C et al. Molecular Profiling and Functional Analysis of Macrophage-Derived Tumor Extracellular Vesicles. Cell Rep 27:3062-3080.e11 (2019). PubMed: 31167148
