Overview

  • Product name

    Anti-Thymidine Phosphorylase antibody
    See all Thymidine Phosphorylase primary antibodies
  • Description

    Rabbit polyclonal to Thymidine Phosphorylase
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-P, WB, ICC/IFmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Recombinant fragment within Human Thymidine Phosphorylase (internal sequence). The exact sequence is proprietary.
    Database link: P19971

  • Positive control

    • WB: NCI-H929 whole cell extract. IHC-P: Human oral CA SCC25 xenograft tissue. ICC/IF: A431 cells.

Properties

Applications

Our Abpromise guarantee covers the use of ab226917 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/100 - 1/1000.
WB 1/500 - 1/3000. Predicted molecular weight: 50 kDa.
ICC/IF 1/100 - 1/1000.

Target

  • Function

    May have a role in maintaining the integrity of the blood vessels. Has growth promoting activity on endothelial cells, angiogenic activity in vivo and chemotactic activity on endothelial cells in vitro.
    Catalyzes the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.
  • Pathway

    Pyrimidine metabolism; dTMP biosynthesis via salvage pathway; dTMP from thymine: step 1/2.
  • Involvement in disease

    Mitochondrial DNA depletion syndrome 1 (MTDPS1) [MIM:603041]: A multisystem disease associated with mitochondrial dysfunction. It is clinically characterized by onset between the second and fifth decades of life, ptosis, progressive external ophthalmoplegia, gastrointestinal dysmotility (often pseudoobstruction), diffuse leukoencephalopathy, cachexia, peripheral neuropathy, and myopathy. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Sequence similarities

    Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.
  • Information by UniProt
  • Database links

  • Alternative names

    • ECGF 1 antibody
    • ECGF antibody
    • ECGF1 antibody
    • Endothelial cell growth factor 1 antibody
    • Endothelial cell growth factor 1 platelet derived antibody
    • Endothelial cell growth factor, platelet-derived antibody
    • Gliostatin antibody
    • hPD ECGF antibody
    • MEDPS1 antibody
    • MNGIE antibody
    • MTDPS1 antibody
    • PD ECGF antibody
    • PD-ECGF antibody
    • PDECGF antibody
    • PDEGF antibody
    • Platelet derived endothelial cell growth factor antibody
    • Platelet derived endothelial growth factor antibody
    • Platelet-derived endothelial cell growth factor antibody
    • TdRPase antibody
    • Thymidine phosphorylase antibody
    • TP antibody
    • Tymp antibody
    • TYPH_HUMAN antibody
    see all

Images

  • Paraffin-embedded human oral CA SCC25 xenograft tissue stained for Thymidine Phosphorylase using ab226917 at 1/100 dilution in immunohistochemical analysis.

  • Anti-Thymidine Phosphorylase antibody (ab226917) at 1/1000 dilution + NCI-H929 (human bone marrow B lymphoblast) whole cell extract at 30 µg

    Predicted band size: 50 kDa



    10% SDS-PAGE gel.

  • Methanol-fixed A431 (human epidermoid carcinoma cell line) cells labeling Thymidine Phosphorylase (green) using ab226917 at 1/500 dilution in ICC/IF. Nuclear counterstained with Hoechst 33342 (blue).

References

ab226917 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab226917.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
For licensing inquiries, please contact partnerships@abcam.com

Sign up