• Product name
    Anti-Thymidine Phosphorylase antibody
    See all Thymidine Phosphorylase primary antibodies
  • Description
    Rabbit polyclonal to Thymidine Phosphorylase
  • Host species
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Rat, Human
    Predicted to work with: Chimpanzee
  • Immunogen

    Synthetic peptide conjugated to KLH derived from within residues 1 - 100 of Human Thymidine Phosphorylase.

    (Peptide available as ab69119.)

  • Positive control
    • This antibody gave a positive signal in the following Lysates: HeLa Whole Cell A431 Whole Cell HeLa Whole Cell - Bleomycin Treated (40 µM) A549 Whole Cell Rat Thymus Tissue (data not shown)



Our Abpromise guarantee covers the use of ab69120 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Detects a band of approximately 50 kDa (predicted molecular weight: 50 kDa).


  • Function
    May have a role in maintaining the integrity of the blood vessels. Has growth promoting activity on endothelial cells, angiogenic activity in vivo and chemotactic activity on endothelial cells in vitro.
    Catalyzes the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.
  • Pathway
    Pyrimidine metabolism; dTMP biosynthesis via salvage pathway; dTMP from thymine: step 1/2.
  • Involvement in disease
    Mitochondrial DNA depletion syndrome 1 (MTDPS1) [MIM:603041]: A multisystem disease associated with mitochondrial dysfunction. It is clinically characterized by onset between the second and fifth decades of life, ptosis, progressive external ophthalmoplegia, gastrointestinal dysmotility (often pseudoobstruction), diffuse leukoencephalopathy, cachexia, peripheral neuropathy, and myopathy. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Sequence similarities
    Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.
  • Information by UniProt
  • Database links
  • Alternative names
    • ECGF 1 antibody
    • ECGF antibody
    • ECGF1 antibody
    • Endothelial cell growth factor 1 antibody
    • Endothelial cell growth factor 1 platelet derived antibody
    • Endothelial cell growth factor, platelet-derived antibody
    • Gliostatin antibody
    • hPD ECGF antibody
    • MEDPS1 antibody
    • MNGIE antibody
    • MTDPS1 antibody
    • PD ECGF antibody
    • PD-ECGF antibody
    • PDECGF antibody
    • PDEGF antibody
    • Platelet derived endothelial cell growth factor antibody
    • Platelet derived endothelial growth factor antibody
    • Platelet-derived endothelial cell growth factor antibody
    • TdRPase antibody
    • Thymidine phosphorylase antibody
    • TP antibody
    • Tymp antibody
    • TYPH_HUMAN antibody
    see all


  • All lanes : Anti-Thymidine Phosphorylase antibody (ab69120) at 1 µg/ml

    Lane 1 : HeLa (Human epithelial carcinoma cell line) Whole Cell Lysate
    Lane 2 : A431 (Human epithelial carcinoma cell line) Whole Cell Lysate
    Lane 3 : HeLa Whole Cell Lysate - Bleomycin Treated (40 µM)
    Lane 4 : A549 (Human lung adenocarcinoma epithelial cell line) Whole Cell Lysate

    Lysates/proteins at 10 µg per lane.

    All lanes : Goat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilution

    Performed under reducing conditions.

    Predicted band size: 50 kDa
    Observed band size: 50 kDa
    Additional bands at: 40 kDa. We are unsure as to the identity of these extra bands.


This product has been referenced in:
  • Wei Q  et al. Anticancer activity of a thymidine quinoxaline conjugate is modulated by cytosolic thymidine pathways. BMC Cancer 15:159 (2015). WB, IHC . Read more (PubMed: 25881156) »
  • Torres-Torronteras J  et al. Gene Therapy Using a Liver-targeted AAV Vector Restores Nucleoside and Nucleotide Homeostasis in a Murine Model of MNGIE. Mol Ther N/A:N/A (2014). WB . Read more (PubMed: 24448160) »

See all 2 Publications for this product

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