Overview

  • Product name

    Anti-Thymidine Phosphorylase antibody - N-terminal
    See all Thymidine Phosphorylase primary antibodies
  • Description

    Rabbit polyclonal to Thymidine Phosphorylase - N-terminal
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, IHC-P, ICC/IFmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Recombinant full length protein corresponding to Human Thymidine Phosphorylase aa 1-482 (N terminal).
    Database link: P19971

  • Positive control

    • A549 and THP1 cell lysates.

Properties

Applications

Our Abpromise guarantee covers the use of ab180783 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/2000. Predicted molecular weight: 50 kDa.
IHC-P 1/50 - 1/200.
ICC/IF Use at an assay dependent concentration.

Target

  • Function

    May have a role in maintaining the integrity of the blood vessels. Has growth promoting activity on endothelial cells, angiogenic activity in vivo and chemotactic activity on endothelial cells in vitro.
    Catalyzes the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.
  • Pathway

    Pyrimidine metabolism; dTMP biosynthesis via salvage pathway; dTMP from thymine: step 1/2.
  • Involvement in disease

    Mitochondrial DNA depletion syndrome 1 (MTDPS1) [MIM:603041]: A multisystem disease associated with mitochondrial dysfunction. It is clinically characterized by onset between the second and fifth decades of life, ptosis, progressive external ophthalmoplegia, gastrointestinal dysmotility (often pseudoobstruction), diffuse leukoencephalopathy, cachexia, peripheral neuropathy, and myopathy. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Sequence similarities

    Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.
  • Information by UniProt
  • Database links

  • Alternative names

    • ECGF 1 antibody
    • ECGF antibody
    • ECGF1 antibody
    • Endothelial cell growth factor 1 antibody
    • Endothelial cell growth factor 1 platelet derived antibody
    • Endothelial cell growth factor, platelet-derived antibody
    • Gliostatin antibody
    • hPD ECGF antibody
    • MEDPS1 antibody
    • MNGIE antibody
    • MTDPS1 antibody
    • PD ECGF antibody
    • PD-ECGF antibody
    • PDECGF antibody
    • PDEGF antibody
    • Platelet derived endothelial cell growth factor antibody
    • Platelet derived endothelial growth factor antibody
    • Platelet-derived endothelial cell growth factor antibody
    • TdRPase antibody
    • Thymidine phosphorylase antibody
    • TP antibody
    • Tymp antibody
    • TYPH_HUMAN antibody
    see all

Images

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human stomach cancer tissue labelling Thymidine Phosphorylase with ab180783 at 1/100. Magnification: 200x.
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human stomach tissue labelling Thymidine Phosphorylase with ab180783 at 1/100. Magnification: 200x.
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human lung cancer tissue labelling Thymidine Phosphorylase with ab180783 at 1/100. Magnification: 200x.
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human kidney cancer tissue labelling Thymidine Phosphorylase with ab180783 at 1/100. Magnification: 200x.
  • Immunocytochemistry/Immunofluorescence analysis of HeLa cells using ab180783. Blue DAPI for nuclear staining.
  • All lanes : Anti-Thymidine Phosphorylase antibody - N-terminal (ab180783) at 1/500 dilution

    Lane 1 : A549 cell lysate
    Lane 2 : THP1 cell lysate

    Predicted band size: 50 kDa

References

ab180783 has not yet been referenced specifically in any publications.

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