Key features and details
- Rabbit polyclonal to Thymidine Phosphorylase - N-terminal
- Suitable for: WB, IHC-P, ICC/IF
- Reacts with: Human
- Isotype: IgG
Product nameAnti-Thymidine Phosphorylase antibody - N-terminal
See all Thymidine Phosphorylase primary antibodies
DescriptionRabbit polyclonal to Thymidine Phosphorylase - N-terminal
Tested applicationsSuitable for: WB, IHC-P, ICC/IFmore details
Species reactivityReacts with: Human
Predicted to work with: Mouse, Rat
Recombinant full length protein corresponding to Human Thymidine Phosphorylase aa 1-482 (N terminal).
Database link: P19971
- A549 and THP1 cell lysates.
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Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferpH: 7.30
Preservative: 0.02% Sodium azide
Constituents: 49% PBS, 50% Glycerol
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab180783 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/500 - 1/2000. Predicted molecular weight: 50 kDa.|
|IHC-P||1/50 - 1/200.|
|ICC/IF||Use at an assay dependent concentration.|
FunctionMay have a role in maintaining the integrity of the blood vessels. Has growth promoting activity on endothelial cells, angiogenic activity in vivo and chemotactic activity on endothelial cells in vitro.
Catalyzes the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.
PathwayPyrimidine metabolism; dTMP biosynthesis via salvage pathway; dTMP from thymine: step 1/2.
Involvement in diseaseMitochondrial DNA depletion syndrome 1 (MTDPS1) [MIM:603041]: A multisystem disease associated with mitochondrial dysfunction. It is clinically characterized by onset between the second and fifth decades of life, ptosis, progressive external ophthalmoplegia, gastrointestinal dysmotility (often pseudoobstruction), diffuse leukoencephalopathy, cachexia, peripheral neuropathy, and myopathy. Note=The disease is caused by mutations affecting the gene represented in this entry.
Sequence similaritiesBelongs to the thymidine/pyrimidine-nucleoside phosphorylase family.
- Information by UniProt
- ECGF 1 antibody
- ECGF antibody
- ECGF1 antibody
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human stomach cancer tissue labelling Thymidine Phosphorylase with ab180783 at 1/100. Magnification: 200x.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human stomach tissue labelling Thymidine Phosphorylase with ab180783 at 1/100. Magnification: 200x.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human lung cancer tissue labelling Thymidine Phosphorylase with ab180783 at 1/100. Magnification: 200x.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human kidney cancer tissue labelling Thymidine Phosphorylase with ab180783 at 1/100. Magnification: 200x.
Immunocytochemistry/Immunofluorescence analysis of HeLa cells using ab180783. Blue DAPI for nuclear staining.
All lanes : Anti-Thymidine Phosphorylase antibody - N-terminal (ab180783) at 1/500 dilution
Lane 1 : A549 cell lysate
Lane 2 : THP1 cell lysate
Predicted band size: 50 kDa
ab180783 has not yet been referenced specifically in any publications.