Overview

  • Product name

    Anti-Thymidine Phosphorylase antibody [P-GF.44C]
    See all Thymidine Phosphorylase primary antibodies
  • Description

    Mouse monoclonal [P-GF.44C] to Thymidine Phosphorylase
  • Host species

    Mouse
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Recombinant full length protein corresponding to Human Thymidine Phosphorylase.
    Database link: P19971

  • Positive control

    • Human placenta tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab218381 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 1 - 2 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

(for 30 minutes at RT)

Target

  • Function

    May have a role in maintaining the integrity of the blood vessels. Has growth promoting activity on endothelial cells, angiogenic activity in vivo and chemotactic activity on endothelial cells in vitro.
    Catalyzes the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.
  • Pathway

    Pyrimidine metabolism; dTMP biosynthesis via salvage pathway; dTMP from thymine: step 1/2.
  • Involvement in disease

    Mitochondrial DNA depletion syndrome 1 (MTDPS1) [MIM:603041]: A multisystem disease associated with mitochondrial dysfunction. It is clinically characterized by onset between the second and fifth decades of life, ptosis, progressive external ophthalmoplegia, gastrointestinal dysmotility (often pseudoobstruction), diffuse leukoencephalopathy, cachexia, peripheral neuropathy, and myopathy. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Sequence similarities

    Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.
  • Information by UniProt
  • Database links

  • Alternative names

    • ECGF 1 antibody
    • ECGF antibody
    • ECGF1 antibody
    • Endothelial cell growth factor 1 antibody
    • Endothelial cell growth factor 1 platelet derived antibody
    • Endothelial cell growth factor, platelet-derived antibody
    • Gliostatin antibody
    • hPD ECGF antibody
    • MEDPS1 antibody
    • MNGIE antibody
    • MTDPS1 antibody
    • PD ECGF antibody
    • PD-ECGF antibody
    • PDECGF antibody
    • PDEGF antibody
    • Platelet derived endothelial cell growth factor antibody
    • Platelet derived endothelial growth factor antibody
    • Platelet-derived endothelial cell growth factor antibody
    • TdRPase antibody
    • Thymidine phosphorylase antibody
    • TP antibody
    • Tymp antibody
    • TYPH_HUMAN antibody
    see all

Images

  • Immunohistochemical analysis of formalin-fixed, paraffin-embedded human placenta tissue labeling Thymidine Phosphorylase with ab218381 at 2 µg/mL.

References

ab218381 has not yet been referenced specifically in any publications.

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