Overview

  • Product name

    Anti-Thyroglobulin antibody [1D4]
    See all Thyroglobulin primary antibodies
  • Description

    Mouse monoclonal [1D4] to Thyroglobulin
  • Host species

    Mouse
  • Specificity

    Recognises thyroglobulin in hyperplastic and neoplastic thyroid.
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Full length protein (Human).

  • Positive control

    • Thyroid

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • Storage buffer

    Preservative: 0.05% Sodium azide
    Constituents: Tissue culture supernatant, 1% BSA
  • Purity

    Tissue culture supernatant
  • Clonality

    Monoclonal
  • Clone number

    1D4
  • Isotype

    IgG2a
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab16853 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P
  • Application notes
    IHC-P: 1/25 - 1/50 in an ABC method.

    Not tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function

      Precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3).
    • Tissue specificity

      Thyroid gland specific.
    • Involvement in disease

      Defects in TG are the cause of congenital hypothyroidism due to dyshormonogenesis type 3 (CHDH3) [MIM:274700]. A disorder due to thyroid dyshormonogenesis, causing large goiters of elastic and soft consistency in the majority of patients. Although the degree of thyroid dysfunction varies considerably among patients with defective thyroglobulin synthesis, patients usually have a relatively high serum free triiodothyronine (T3) concentration with disproportionately low free tetraiodothyronine (T4) level. The maintenance of relatively high free T3 levels prevents profound tissue hypothyroidism except in brain and pituitary, which are dependent on T4 supply, resulting in neurologic and intellectual defects in some cases.
      Variations in TG are associated with susceptibility to autoimmune thyroid disease type 3 (AITD3) [MIM:608175]. AITDs including Graves disease (GD) and Hashimoto thyroiditis (HT), are among the most common human autoimmune diseases. They are complex diseases, which are caused by an interaction between susceptibility genes and nongenetic factors, such as infection.
    • Sequence similarities

      Belongs to the type-B carboxylesterase/lipase family.
      Contains 11 thyroglobulin type-1 domains.
    • Post-translational
      modifications

      Sulfated tyrosines are desulfated during iodination.
    • Cellular localization

      Secreted.
    • Information by UniProt
    • Database links

    • Alternative names

      • AITD 3 antibody
      • AITD3 antibody
      • hTG antibody
      • TDH3 antibody
      • Tg antibody
      • TGN antibody
      • THYG_HUMAN antibody
      • Thyroglobulin antibody
      see all

    References

    ab16853 has not yet been referenced specifically in any publications.

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