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    thyroglobulin-antibody-1d4-ab16853.pdf

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Anti-Thyroglobulin antibody [1D4] (ab16853)

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Thyroglobulin antibody [1D4] (ab16853)

    Key features and details

    • Mouse monoclonal [1D4] to Thyroglobulin
    • Suitable for: IHC-P
    • Reacts with: Human
    • Isotype: IgG2a

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    Recombinant Human Thyroglobulin protein (ab152743)
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    Overview

    • Product name

      Anti-Thyroglobulin antibody [1D4]
      See all Thyroglobulin primary antibodies
    • Description

      Mouse monoclonal [1D4] to Thyroglobulin
    • Host species

      Mouse
    • Specificity

      Recognises thyroglobulin in hyperplastic and neoplastic thyroid.
    • Tested applications

      Suitable for: IHC-Pmore details
    • Species reactivity

      Reacts with: Human
    • Immunogen

      Full length protein (Human).

    • Positive control

      • Thyroid
    • General notes

      The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

      If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As

    Properties

    • Form

      Liquid
    • Storage instructions

      Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.
    • Storage buffer

      pH: 7.3
      Preservative: 0.05% Sodium azide
      Constituents: Tissue culture supernatant, 1% BSA
    • Concentration information loading...
    • Purity

      Tissue culture supernatant
    • Clonality

      Monoclonal
    • Clone number

      1D4
    • Isotype

      IgG2a
    • Research areas

      • Signal Transduction
      • Growth Factors/Hormones
      • Hormones
      • Cancer
      • Tumor biomarkers
      • Globulins

    Associated products

    • Compatible Secondaries

      • Goat Anti-Mouse IgG H&L (Alexa Fluor® 488) (ab150113)
      • Goat Anti-Mouse IgG H&L (HRP) (ab205719)
    • Isotype control

      • Mouse IgG2a, kappa monoclonal [MG2a-53] - Isotype control (ab18415)
    • Recombinant Protein

      • Recombinant Human Thyroglobulin protein (ab152743)

    Applications

    The Abpromise guarantee

    Our Abpromise guarantee covers the use of ab16853 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Abreviews Notes
    IHC-P
    Use at an assay dependent concentration.
    Notes
    IHC-P
    Use at an assay dependent concentration.

    Target

    • Function

      Precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3).
    • Tissue specificity

      Thyroid gland specific.
    • Involvement in disease

      Defects in TG are the cause of congenital hypothyroidism due to dyshormonogenesis type 3 (CHDH3) [MIM:274700]. A disorder due to thyroid dyshormonogenesis, causing large goiters of elastic and soft consistency in the majority of patients. Although the degree of thyroid dysfunction varies considerably among patients with defective thyroglobulin synthesis, patients usually have a relatively high serum free triiodothyronine (T3) concentration with disproportionately low free tetraiodothyronine (T4) level. The maintenance of relatively high free T3 levels prevents profound tissue hypothyroidism except in brain and pituitary, which are dependent on T4 supply, resulting in neurologic and intellectual defects in some cases.
      Variations in TG are associated with susceptibility to autoimmune thyroid disease type 3 (AITD3) [MIM:608175]. AITDs including Graves disease (GD) and Hashimoto thyroiditis (HT), are among the most common human autoimmune diseases. They are complex diseases, which are caused by an interaction between susceptibility genes and nongenetic factors, such as infection.
    • Sequence similarities

      Belongs to the type-B carboxylesterase/lipase family.
      Contains 11 thyroglobulin type-1 domains.
    • Post-translational
      modifications

      Sulfated tyrosines are desulfated during iodination.
    • Cellular localization

      Secreted.
    • Target information above from: UniProt accession P01266 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt
    • Database links

      • Entrez Gene: 7038 Human
      • Omim: 188450 Human
      • SwissProt: P01266 Human
      • Unigene: 654591 Human
      • Alternative names

        • AITD 3 antibody
        • AITD3 antibody
        • hTG antibody
        • TDH3 antibody
        • Tg antibody
        • TGN antibody
        • THYG_HUMAN antibody
        • Thyroglobulin antibody
        see all

      Images

      • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Thyroglobulin antibody [1D4] (ab16853)
        Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Thyroglobulin antibody [1D4] (ab16853)

        Immunohistochemistry (Formalin fixed paraffin-embedded sections) analysis of human thyroid tissue labelling Amyloid A Component with ab16853.

      Protocols

      • Immunohistochemistry protocols

      Click here to view the general protocols

      Datasheets and documents

      • SDS download

      • Datasheet download

        Download

      References (0)

      Publishing research using ab16853? Please let us know so that we can cite the reference in this datasheet.

      ab16853 has not yet been referenced specifically in any publications.

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