Anti-Thyroglobulin antibody [5F9] (ab1984)

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Key features and details

  • Mouse monoclonal [5F9] to Thyroglobulin
  • Reacts with: Cow, Human
  • Isotype: IgG2a

Overview

  • Product name

    Anti-Thyroglobulin antibody [5F9]
    See all Thyroglobulin primary antibodies

  • Description

    Mouse monoclonal [5F9] to Thyroglobulin

  • Host species

    Mouse

  • Specificity

    This antibody does not interfere with anti-thyroglobulin autoantibodies.

  • Species reactivity

    Reacts with: Cow, Human

  • Immunogen

    Full length native protein (purified) corresponding to Thyroglobulin.

  • General notes

    Concentration varies from lot to lot and can be provided on request.

    The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

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Properties

Target

  • Function

    Precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3).

  • Tissue specificity

    Thyroid gland specific.

  • Involvement in disease

    Defects in TG are the cause of congenital hypothyroidism due to dyshormonogenesis type 3 (CHDH3) [MIM:274700]. A disorder due to thyroid dyshormonogenesis, causing large goiters of elastic and soft consistency in the majority of patients. Although the degree of thyroid dysfunction varies considerably among patients with defective thyroglobulin synthesis, patients usually have a relatively high serum free triiodothyronine (T3) concentration with disproportionately low free tetraiodothyronine (T4) level. The maintenance of relatively high free T3 levels prevents profound tissue hypothyroidism except in brain and pituitary, which are dependent on T4 supply, resulting in neurologic and intellectual defects in some cases.
    Variations in TG are associated with susceptibility to autoimmune thyroid disease type 3 (AITD3) [MIM:608175]. AITDs including Graves disease (GD) and Hashimoto thyroiditis (HT), are among the most common human autoimmune diseases. They are complex diseases, which are caused by an interaction between susceptibility genes and nongenetic factors, such as infection.

  • Sequence similarities

    Belongs to the type-B carboxylesterase/lipase family.
    Contains 11 thyroglobulin type-1 domains.

  • Post-translational
    modifications

    Sulfated tyrosines are desulfated during iodination.

  • Cellular localization

    Secreted.
  • Information by UniProt

  • Database links

    • Alternative names

      • AITD 3 antibody
      • AITD3 antibody
      • hTG antibody
      • TDH3 antibody
      • Tg antibody
      • TGN antibody
      • THYG_HUMAN antibody
      • Thyroglobulin antibody
      see all

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    References (0)

    Publishing research using ab1984? Please let us know so that we can cite the reference in this datasheet.

    ab1984 has not yet been referenced specifically in any publications.

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