Anti-Thyroglobulin antibody [5F9] (ab1984)
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Overview
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Product nameAnti-Thyroglobulin antibody [5F9]
See all Thyroglobulin primary antibodies -
DescriptionMouse monoclonal [5F9] to Thyroglobulin
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Host speciesMouse
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SpecificityThis antibody does not interfere with anti-thyroglobulin autoantibodies.
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Tested applicationsSuitable for: ELISAmore details
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Species reactivityReacts with: Cow, Human
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Immunogen
Thyroglobulin from human thyroid gland.
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General notesConcentration varies from lot to lot and can be provided on request.
Properties
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FormLiquid
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Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
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Storage bufferPreservative: 0.1% Sodium azide
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Concentration information loading... -
PurityProtein G purified
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Purification notesPurity is tested by electrophoresis.
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ClonalityMonoclonal
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Clone number5F9
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MyelomaSp2/0
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IsotypeIgG2a
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Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
Our Abpromise guarantee covers the use of ab1984 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| ELISA | Use at an assay dependent concentration. Can be used in an ELISA pair with ab1982 (conjugate). |
Target
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FunctionPrecursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3).
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Tissue specificityThyroid gland specific.
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Involvement in diseaseDefects in TG are the cause of congenital hypothyroidism due to dyshormonogenesis type 3 (CHDH3) [MIM:274700]. A disorder due to thyroid dyshormonogenesis, causing large goiters of elastic and soft consistency in the majority of patients. Although the degree of thyroid dysfunction varies considerably among patients with defective thyroglobulin synthesis, patients usually have a relatively high serum free triiodothyronine (T3) concentration with disproportionately low free tetraiodothyronine (T4) level. The maintenance of relatively high free T3 levels prevents profound tissue hypothyroidism except in brain and pituitary, which are dependent on T4 supply, resulting in neurologic and intellectual defects in some cases.
Variations in TG are associated with susceptibility to autoimmune thyroid disease type 3 (AITD3) [MIM:608175]. AITDs including Graves disease (GD) and Hashimoto thyroiditis (HT), are among the most common human autoimmune diseases. They are complex diseases, which are caused by an interaction between susceptibility genes and nongenetic factors, such as infection. -
Sequence similaritiesBelongs to the type-B carboxylesterase/lipase family.
Contains 11 thyroglobulin type-1 domains. -
Post-translational
modificationsSulfated tyrosines are desulfated during iodination. -
Cellular localizationSecreted.
- Information by UniProt
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Database links
- Entrez Gene: 280706 Cow
- Entrez Gene: 7038 Human
- Omim: 188450 Human
- SwissProt: P01267 Cow
- SwissProt: P01266 Human
- Unigene: 654591 Human
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Alternative names
- AITD 3 antibody
- AITD3 antibody
- hTG antibody
see all
References
ab1984 has not yet been referenced specifically in any publications.
