Key features and details
- Rabbit polyclonal to Thyroglobulin
- Suitable for: IHC-P, IHC-Fr, ICC/IF
- Reacts with: Human
- Isotype: IgG
Product nameAnti-Thyroglobulin antibody
See all Thyroglobulin primary antibodies
DescriptionRabbit polyclonal to Thyroglobulin
Tested applicationsSuitable for: IHC-P, IHC-Fr, ICC/IFmore details
Species reactivityReacts with: Human
Purified Human Thyroglobulin.
- Human thyroid
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.
Storage bufferpH: 7.40
Preservative: 0.05% Sodium azide
Constituents: 98% PBS, 1% BSA
Concentration information loading...
Our Abpromise guarantee covers the use of ab124472 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IHC-P||1/50 - 1/100.|
|IHC-Fr||1/50 - 1/100.|
|ICC/IF||1/50 - 1/100.|
FunctionPrecursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3).
Tissue specificityThyroid gland specific.
Involvement in diseaseDefects in TG are the cause of congenital hypothyroidism due to dyshormonogenesis type 3 (CHDH3) [MIM:274700]. A disorder due to thyroid dyshormonogenesis, causing large goiters of elastic and soft consistency in the majority of patients. Although the degree of thyroid dysfunction varies considerably among patients with defective thyroglobulin synthesis, patients usually have a relatively high serum free triiodothyronine (T3) concentration with disproportionately low free tetraiodothyronine (T4) level. The maintenance of relatively high free T3 levels prevents profound tissue hypothyroidism except in brain and pituitary, which are dependent on T4 supply, resulting in neurologic and intellectual defects in some cases.
Variations in TG are associated with susceptibility to autoimmune thyroid disease type 3 (AITD3) [MIM:608175]. AITDs including Graves disease (GD) and Hashimoto thyroiditis (HT), are among the most common human autoimmune diseases. They are complex diseases, which are caused by an interaction between susceptibility genes and nongenetic factors, such as infection.
Sequence similaritiesBelongs to the type-B carboxylesterase/lipase family.
Contains 11 thyroglobulin type-1 domains.
modificationsSulfated tyrosines are desulfated during iodination.
- Information by UniProt
- AITD 3 antibody
- AITD3 antibody
- hTG antibody
ab124472 has not yet been referenced specifically in any publications.