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    thyroglobulin-antibody-ab48628.pdf

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Signal Transduction Growth Factors/Hormones Hormones
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Anti-Thyroglobulin antibody (ab48628)

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Western blot - Anti-Thyroglobulin antibody (ab48628)

    Key features and details

    • Rabbit polyclonal to Thyroglobulin
    • Suitable for: WB
    • Reacts with: Human
    • Isotype: IgG

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    Protein
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    Recombinant Human Thyroglobulin protein (ab152743)
    Secondary
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    Goat Anti-Rabbit IgG H&L (HRP) (ab205718)

    View more associated products

    Overview

    • Product name

      Anti-Thyroglobulin antibody
      See all Thyroglobulin primary antibodies
    • Description

      Rabbit polyclonal to Thyroglobulin
    • Host species

      Rabbit
    • Tested applications

      Suitable for: WBmore details
    • Species reactivity

      Reacts with: Human
    • Immunogen

      Full length native protein (purified from plasma) (Human)

    Properties

    • Form

      Liquid
    • Storage instructions

      Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
    • Storage buffer

      pH: 7.50
      Preservative: 0.01% Thimerosal (merthiolate)
      Constituents: PBS, 50% Glycerol
    • Concentration information loading...
    • Purity

      Protein G purified
    • Clonality

      Polyclonal
    • Isotype

      IgG
    • Research areas

      • Signal Transduction
      • Growth Factors/Hormones
      • Hormones
      • Cancer
      • Tumor biomarkers
      • Globulins

    Associated products

    • Compatible Secondaries

      • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
      • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
    • Isotype control

      • Rabbit IgG, polyclonal - Isotype Control (ChIP Grade) (ab171870)
    • Recombinant Protein

      • Recombinant Human Thyroglobulin protein (ab152743)

    Applications

    Our Abpromise guarantee covers the use of ab48628 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Abreviews Notes
    WB Use at an assay dependent concentration. Predicted molecular weight: 307 kDa.

    Target

    • Function

      Precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3).
    • Tissue specificity

      Thyroid gland specific.
    • Involvement in disease

      Defects in TG are the cause of congenital hypothyroidism due to dyshormonogenesis type 3 (CHDH3) [MIM:274700]. A disorder due to thyroid dyshormonogenesis, causing large goiters of elastic and soft consistency in the majority of patients. Although the degree of thyroid dysfunction varies considerably among patients with defective thyroglobulin synthesis, patients usually have a relatively high serum free triiodothyronine (T3) concentration with disproportionately low free tetraiodothyronine (T4) level. The maintenance of relatively high free T3 levels prevents profound tissue hypothyroidism except in brain and pituitary, which are dependent on T4 supply, resulting in neurologic and intellectual defects in some cases.
      Variations in TG are associated with susceptibility to autoimmune thyroid disease type 3 (AITD3) [MIM:608175]. AITDs including Graves disease (GD) and Hashimoto thyroiditis (HT), are among the most common human autoimmune diseases. They are complex diseases, which are caused by an interaction between susceptibility genes and nongenetic factors, such as infection.
    • Sequence similarities

      Belongs to the type-B carboxylesterase/lipase family.
      Contains 11 thyroglobulin type-1 domains.
    • Post-translational
      modifications

      Sulfated tyrosines are desulfated during iodination.
    • Cellular localization

      Secreted.
    • Target information above from: UniProt accession P01266 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt
    • Database links

      • Entrez Gene: 7038 Human
      • Omim: 188450 Human
      • SwissProt: P01266 Human
      • Unigene: 654591 Human
      • Alternative names

        • AITD 3 antibody
        • AITD3 antibody
        • hTG antibody
        • TDH3 antibody
        • Tg antibody
        • TGN antibody
        • THYG_HUMAN antibody
        • Thyroglobulin antibody
        see all

      Images

      • Western blot - Anti-Thyroglobulin antibody (ab48628)
        Western blot - Anti-Thyroglobulin antibody (ab48628)

      Protocols

      • Western blot protocols

      Click here to view the general protocols

      Datasheets and documents

      • Datasheet
      • SDS
    • References (0)

      Publishing research using ab48628? Please let us know so that we can cite the reference in this datasheet.

      ab48628 has not yet been referenced specifically in any publications.

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