Recombinant
RabMAb

Recombinant Anti-Thyroglobulin antibody [EPR3614(2)] (ab151539)

Overview

  • Product name

    Anti-Thyroglobulin antibody [EPR3614(2)]
    See all Thyroglobulin primary antibodies
  • Description

    Rabbit monoclonal [EPR3614(2)] to Thyroglobulin
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, IHC-P, IPmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Synthetic peptide within Human Thyroglobulin. The exact sequence is proprietary.

  • Positive control

    • Human thyroid lysate; Human thyroid gland follicular carcinoma tissue.
  • General notes

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents.

    This product is a recombinant rabbit monoclonal antibody.

Properties

Applications

Our Abpromise guarantee covers the use of ab151539 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100000 - 1/500000. Predicted molecular weight: 305 kDa.
IHC-P 1/250 - 1/500.
IP 1/10 - 1/100.

Target

  • Function

    Precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3).
  • Tissue specificity

    Thyroid gland specific.
  • Involvement in disease

    Defects in TG are the cause of congenital hypothyroidism due to dyshormonogenesis type 3 (CHDH3) [MIM:274700]. A disorder due to thyroid dyshormonogenesis, causing large goiters of elastic and soft consistency in the majority of patients. Although the degree of thyroid dysfunction varies considerably among patients with defective thyroglobulin synthesis, patients usually have a relatively high serum free triiodothyronine (T3) concentration with disproportionately low free tetraiodothyronine (T4) level. The maintenance of relatively high free T3 levels prevents profound tissue hypothyroidism except in brain and pituitary, which are dependent on T4 supply, resulting in neurologic and intellectual defects in some cases.
    Variations in TG are associated with susceptibility to autoimmune thyroid disease type 3 (AITD3) [MIM:608175]. AITDs including Graves disease (GD) and Hashimoto thyroiditis (HT), are among the most common human autoimmune diseases. They are complex diseases, which are caused by an interaction between susceptibility genes and nongenetic factors, such as infection.
  • Sequence similarities

    Belongs to the type-B carboxylesterase/lipase family.
    Contains 11 thyroglobulin type-1 domains.
  • Post-translational
    modifications

    Sulfated tyrosines are desulfated during iodination.
  • Cellular localization

    Secreted.
  • Information by UniProt
  • Database links

  • Alternative names

    • AITD 3 antibody
    • AITD3 antibody
    • hTG antibody
    • TDH3 antibody
    • Tg antibody
    • TGN antibody
    • THYG_HUMAN antibody
    • Thyroglobulin antibody
    see all

Images

  • Immunohistochemical analysis of paraffin-embedded Human thyroid gland follicular carcinoma tissue labeling Thyroglobulin with ab151539 at 1/250 dilution.
  • Anti-Thyroglobulin antibody [EPR3614(2)] (ab151539) at 1/100000 dilution + Human thyroid lysate at 10 µg

    Secondary
    Goat anti-rabbit HRP at 1/2000 dilution

    Predicted band size: 305 kDa

  • Immunohistochemical analysis of paraffin embedded Human Skeletal muscle tissue using ab151539 showing -ve staining.

  • Immunohistochemical analysis of paraffin embedded normal Human prostate tissue using ab151539 showing -ve staining.

  • Immunohistochemical analysis of paraffin embedded Human Thyroid gland tissue using ab151539 showing +ve staining.

References

ab151539 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab151539.
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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
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