Product nameAnti-Thyroglobulin antibody [EPR9730(IHC)] - BSA and Azide free
See all Thyroglobulin primary antibodies
DescriptionRabbit monoclonal [EPR9730(IHC)] to Thyroglobulin - BSA and Azide free
Tested applicationsSuitable for: IHC-P, ICC/IFmore details
Unsuitable for: IP or WB
Species reactivityReacts with: Human
Does not react with: Mouse, Rat
Recombinant full length protein corresponding to Human Thyroglobulin aa 1-2800.
Database link: P01266
Ab249444 is the carrier-free version of ab168344. This format is designed for use in antibody labeling, including fluorochromes, metal isotopes, oligonucleotides, enzymes.
Our carrier-free formats are supplied in a buffer free of BSA, sodium azide and glycerol for higher conjugation efficiency.
Use our conjugation kits for antibody conjugates that are ready-to-use in as little as 20 minutes with <1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
ab249444 is compatible with the Maxpar® Antibody Labeling Kit from Fluidigm.
Maxpar® is a trademark of Fluidigm Canada Inc.
This product is a recombinant monoclonal antibody, which offers several advantages including:
- - High batch-to-batch consistency and reproducibility
- - Improved sensitivity and specificity
- - Long-term security of supply
- - Animal-free production
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferConstituent: PBS
Concentration information loading...
- Anti-Thyroglobulin antibody [EPR9730] (ab156008)
- Anti-Thyroglobulin antibody [EPR9730(IHC)] (ab168344)
- Anti-Thyroglobulin antibody [EPR9730] (Alexa Fluor® 488) (ab214872)
- Anti-Thyroglobulin antibody [EPR9730] (Alexa Fluor® 647) (ab215938)
- Anti-Thyroglobulin antibody [EPR9730] - Low endotoxin, Azide free (ab229449)
Our Abpromise guarantee covers the use of ab249444 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IHC-P||Use at an assay dependent concentration. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.|
|ICC/IF||Use at an assay dependent concentration.|
FunctionPrecursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3).
Tissue specificityThyroid gland specific.
Involvement in diseaseDefects in TG are the cause of congenital hypothyroidism due to dyshormonogenesis type 3 (CHDH3) [MIM:274700]. A disorder due to thyroid dyshormonogenesis, causing large goiters of elastic and soft consistency in the majority of patients. Although the degree of thyroid dysfunction varies considerably among patients with defective thyroglobulin synthesis, patients usually have a relatively high serum free triiodothyronine (T3) concentration with disproportionately low free tetraiodothyronine (T4) level. The maintenance of relatively high free T3 levels prevents profound tissue hypothyroidism except in brain and pituitary, which are dependent on T4 supply, resulting in neurologic and intellectual defects in some cases.
Variations in TG are associated with susceptibility to autoimmune thyroid disease type 3 (AITD3) [MIM:608175]. AITDs including Graves disease (GD) and Hashimoto thyroiditis (HT), are among the most common human autoimmune diseases. They are complex diseases, which are caused by an interaction between susceptibility genes and nongenetic factors, such as infection.
Sequence similaritiesBelongs to the type-B carboxylesterase/lipase family.
Contains 11 thyroglobulin type-1 domains.
modificationsSulfated tyrosines are desulfated during iodination.
- Information by UniProt
- AITD 3 antibody
- AITD3 antibody
- hTG antibody
ab249444 has not yet been referenced specifically in any publications.