Anti-Thyroid Hormone Receptor alpha 1+2 antibody, prediluted (ab15544)

Overview

  • Product name
    Anti-Thyroid Hormone Receptor alpha 1+2 antibody, prediluted
    See all Thyroid Hormone Receptor alpha 1+2 primary antibodies
  • Description
    Rabbit polyclonal to Thyroid Hormone Receptor alpha 1+2, prediluted
  • Host species
    Rabbit
  • Tested applications
    Suitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Pig
  • Immunogen

    Synthetic peptide within Human Thyroid Hormone Receptor alpha 1+2 aa 1-100. The exact sequence is proprietary.

  • Positive control
    • Colon carcinoma.

Properties

Applications

Our Abpromise guarantee covers the use of ab15544 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P
  • Application notes
    IHC-P: Use at an assay dependent dilution. Staining of formalin fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0 for 10 min followed by cooling at room temperature for 20 min.

    Not tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      Isoform Alpha-1: Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.
      Isoform Alpha-2: Does not bind thyroid hormone and functions as a weak dominant negative inhibitor of thyroid hormone action.
    • Involvement in disease
      Hypothyroidism, congenital, non-goitrous, 6
    • Sequence similarities
      Belongs to the nuclear hormone receptor family. NR1 subfamily.
      Contains 1 nuclear receptor DNA-binding domain.
    • Domain
      Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
    • Cellular localization
      Nucleus.
    • Information by UniProt
    • Database links
    • Alternative names
      • c-erbA-1 antibody
      • C-erbA-alpha antibody
      • EAR-7 antibody
      • ERBA 1 antibody
      • ERBA antibody
      • ERBA related 7 antibody
      • Nuclear receptor subfamily 1 group A member 1 antibody
      • THA_HUMAN antibody
      • THRA antibody
      • Thra1 antibody
      • Thra2 antibody
      • Thyroid hormone receptor alpha 1 antibody
      • Thyroid hormone receptor alpha 2 antibody
      • Thyroid hormone receptor alpha antibody
      • TR alpha 1 antibody
      • TR alpha 2 antibody
      • Tra1 antibody
      • Triiodothyronine receptor antibody
      • V-erbA-related protein 7 antibody
      see all

    Images

    • ab15544 staining thyroid hormone receptor alpha 1 and 2 in colon carcinoma by Immunohistochemistry (formalin/paraffin).

    References

    ab15544 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

    Thank you for your enquiry. Unfortunately, we don't have the corresponding peptides for these antibodies. If you cannot find what you are looking for within the Abcam catalogue, you can click on the link to "The World's Antibody Gateway". The World's ...

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