Key features and details
- Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
- Rabbit monoclonal [EPR7862] to Thyroid Hormone Receptor alpha
- Suitable for: WB
- Reacts with: Human
Product nameAnti-Thyroid Hormone Receptor alpha antibody [EPR7862]
See all Thyroid Hormone Receptor alpha primary antibodies
DescriptionRabbit monoclonal [EPR7862] to Thyroid Hormone Receptor alpha
Tested applicationsSuitable for: WBmore details
Unsuitable for: Flow Cyt,ICC/IF,IHC-P or IP
Species reactivityReacts with: Human
Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) within Human Thyroid Hormone Receptor alpha aa 400 to the C-terminus (Cysteine residue). The exact sequence is proprietary.
Database link: P10827
- WB: Jurkat, MEF, NIH/3T3, Molt-4 and MCF-7 cell lysates.
Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.
This product is a recombinant monoclonal antibody, which offers several advantages including:
- - High batch-to-batch consistency and reproducibility
- - Improved sensitivity and specificity
- - Long-term security of supply
- - Animal-free production
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferpH: 7.20
Preservative: 0.01% Sodium azide
Constituents: 9% PBS, 40% Glycerol, 0.05% BSA, 50% Tissue culture supernatant
Concentration information loading...
PurityTissue culture supernatant
Our Abpromise guarantee covers the use of ab179438 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/1000 - 1/5000. Predicted molecular weight: 55 kDa.|
FunctionNuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.
Involvement in diseaseHypothyroidism, congenital, non-goitrous, 6
Sequence similaritiesBelongs to the nuclear hormone receptor family. NR1 subfamily.
Contains 1 nuclear receptor DNA-binding domain.
DomainComposed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
- Information by UniProt
- AR7 antibody
- c-erbA-1 antibody
- C-erbA-alpha antibody
All lanes : Anti-Thyroid Hormone Receptor alpha antibody [EPR7862] (ab179438) at 0.546 µg/ml
Lane 1 : Jurkat (Human T cell leukemia T lymphocyte)
Lane 2 : NIH/3T3(Mouse embryonic fibroblast) whole cell lysate
Lane 3 : MEF (Mouse embryonic fibroblast)
Lysates/proteins at 20 µg per lane.
All lanes : Goat Anti-Rabbit IgG H&L (HRP) (ab97051) at 0.05 µg/ml
Predicted band size: 55 kDa
All lanes : Anti-Thyroid Hormone Receptor alpha antibody [EPR7862] (ab179438) at 1/1000 dilution
Lane 1 : Jurkat cell lysate
Lane 2 : Molt-4 cell lysate
Lane 3 : MCF-7 cell lysate
Lysates/proteins at 10 µg per lane.
Predicted band size: 55 kDa
ab179438 has not yet been referenced specifically in any publications.