Anti-Thyroid Hormone Receptor beta antibody - N-terminal (ab196484)
Key features and details
- Rabbit polyclonal to Thyroid Hormone Receptor beta - N-terminal
- Suitable for: WB
- Reacts with: Mouse, Human
- Isotype: IgG
Overview
-
Product name
Anti-Thyroid Hormone Receptor beta antibody - N-terminal
See all Thyroid Hormone Receptor beta primary antibodies -
Description
Rabbit polyclonal to Thyroid Hormone Receptor beta - N-terminal -
Host species
Rabbit -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Mouse, Human
Predicted to work with: Rat -
Immunogen
Recombinant fragment within Human Thyroid Hormone Receptor beta (N terminal). The exact sequence is proprietary.
Database link: P10828 -
General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
-
Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.40
Preservative: 0.02% Sodium azide
Constituents: 0.87% Sodium chloride, 50% Glycerol (glycerin, glycerine), 49% PBS
PBS is without Mg2+ and Ca2+. -
Concentration information loading...
-
Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
-
Compatible Secondaries
-
Isotype control
-
Positive Controls
-
Recombinant Protein
-
Related Products
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab196484 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
---|---|---|
WB |
1/500 - 1/2000. Predicted molecular weight: 53 kDa.
|
Notes |
---|
WB
1/500 - 1/2000. Predicted molecular weight: 53 kDa. |
Target
-
Function
High affinity receptor for triiodothyronine. -
Involvement in disease
Defects in THRB are the cause of generalized thyroid hormone resistance (GTHR) [MIM:188570, 274300]. GTHR is transmitted as an autosomal dominant trait, but an autosomal recessive form also exists. The disease is characterized by goiter, abnormal mental functions, increased susceptibility to infections, abnormal growth and bone maturation, tachycardia and deafness. Affected individuals may also have attention deficit-hyperactivity disorders (ADHD) and language difficulties. GTHR patients also have high levels of circulating thyroid hormones (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH).
Defects in THRB are the cause of selective pituitary thyroid hormone resistance (PRTH) [MIM:145650]; also known as familial hyperthyroidism due to inappropriate thyrotropin secretion. PRTH is a variant form of thyroid hormone resistance and is characterized by clinical hyperthyroidism, with elevated free thyroid hormones, but inappropriately normal serum TSH. Unlike GRTH, where the syndrome usually segregates with a dominant allele, the mode of inheritance in PRTH has not been established. -
Sequence similarities
Belongs to the nuclear hormone receptor family. NR1 subfamily.
Contains 1 nuclear receptor DNA-binding domain. -
Domain
Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain. -
Cellular localization
Nucleus. - Information by UniProt
-
Database links
- Entrez Gene: 7068 Human
- Entrez Gene: 21834 Mouse
- Entrez Gene: 24831 Rat
- Omim: 190160 Human
- SwissProt: P10828 Human
- SwissProt: P37242 Mouse
- SwissProt: P18113 Rat
- Unigene: 187861 Human
see all -
Alternative names
- Avian erythroblastic leukemia viral (v erb a) oncogene homolog 2 antibody
- C ERBA 2 antibody
- C ERBA BETA antibody
see all
Images
-
All lanes : Anti-Thyroid Hormone Receptor beta antibody - N-terminal (ab196484) at 1/500 dilution
Lane 1 : K562 cell extract
Lane 2 : PC3 cell extract
Lane 3 : HepG2 cell extract
Lane 4 : U251 cell extract
Lane 5 : Mouse liver tissue extract
Lane 6 : Mouse craniofacial tissue extract
Predicted band size: 53 kDa
Datasheets and documents
-
SDS download
-
Datasheet download
References (0)
ab196484 has not yet been referenced specifically in any publications.