Key features and details
- Rabbit polyclonal to Thyroid Hormone Receptor beta - N-terminal
- Suitable for: WB
- Reacts with: Mouse, Human
- Isotype: IgG
Product nameAnti-Thyroid Hormone Receptor beta antibody - N-terminal
See all Thyroid Hormone Receptor beta primary antibodies
DescriptionRabbit polyclonal to Thyroid Hormone Receptor beta - N-terminal
Specificityab196484 detects endogenous level of total Thyroid Hormone Receptor beta protein.
Tested applicationsSuitable for: WBmore details
Species reactivityReacts with: Mouse, Human
Predicted to work with: Rat
Recombinant fragment within Human Thyroid Hormone Receptor beta (N terminal). The exact sequence is proprietary.
Database link: P10828
Storage bufferpH: 7.40
Preservative: 0.02% Sodium azide
Constituents: 0.87% Sodium chloride, 50% Glycerol (glycerin, glycerine), 49% PBS
PBS is without Mg2+ and Ca2+.
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab196484 in the following tested applications.
|WB||1/500 - 1/2000. Predicted molecular weight: 53 kDa.|
FunctionHigh affinity receptor for triiodothyronine.
Involvement in diseaseDefects in THRB are the cause of generalized thyroid hormone resistance (GTHR) [MIM:188570, 274300]. GTHR is transmitted as an autosomal dominant trait, but an autosomal recessive form also exists. The disease is characterized by goiter, abnormal mental functions, increased susceptibility to infections, abnormal growth and bone maturation, tachycardia and deafness. Affected individuals may also have attention deficit-hyperactivity disorders (ADHD) and language difficulties. GTHR patients also have high levels of circulating thyroid hormones (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH).
Defects in THRB are the cause of selective pituitary thyroid hormone resistance (PRTH) [MIM:145650]; also known as familial hyperthyroidism due to inappropriate thyrotropin secretion. PRTH is a variant form of thyroid hormone resistance and is characterized by clinical hyperthyroidism, with elevated free thyroid hormones, but inappropriately normal serum TSH. Unlike GRTH, where the syndrome usually segregates with a dominant allele, the mode of inheritance in PRTH has not been established.
Sequence similaritiesBelongs to the nuclear hormone receptor family. NR1 subfamily.
Contains 1 nuclear receptor DNA-binding domain.
DomainComposed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
- Information by UniProt
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All lanes : Anti-Thyroid Hormone Receptor beta antibody - N-terminal (ab196484) at 1/500 dilution
Lane 1 : K562 cell extract
Lane 2 : PC3 cell extract
Lane 3 : HepG2 cell extract
Lane 4 : U251 cell extract
Lane 5 : Mouse liver tissue extract
Lane 6 : Mouse craniofacial tissue extract
Predicted band size: 53 kDa
ab196484 has not yet been referenced specifically in any publications.