Key features and details
- Mouse monoclonal [MoAb47] to Thyroid Peroxidase/TPO
- Reacts with: Human
- Isotype: IgG1
Product nameAnti-Thyroid Peroxidase/TPO antibody [MoAb47]
See all Thyroid Peroxidase/TPO primary antibodies
DescriptionMouse monoclonal [MoAb47] to Thyroid Peroxidase/TPO
Species reactivityReacts with: Human
Full length native protein (purified) corresponding to Human Thyroid Peroxidase/TPO.
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Storage instructionsShipped at 4°C. Store at +4°C.
Storage bufferPreservative: 0.05% Sodium azide
Constituent: Tissue culture supernatant
Concentration information loading...
PurityTissue culture supernatant
Not tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
FunctionIodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T(3) and T(4).
PathwayHormone biosynthesis; thyroid hormone biosynthesis.
Involvement in diseaseNote=An alternative splicing in the thyroperoxidase mRNA can cause Graves' disease.
Defects in TPO are the cause of congenital hypothyroidism due to dyshormonogenesis type 2A (CHDH2A) [MIM:274500]; also called genetic defect in thyroid hormonogenesis 2A or thyroid hormone organification defect II. CHDH2A is due to defective conversion of accumulated iodide to organically bound iodine. The iodide organification defect can be partial or complete.
Sequence similaritiesBelongs to the peroxidase family. XPO subfamily.
Contains 1 EGF-like domain.
Contains 1 Sushi (CCP/SCR) domain.
Heme is covalently bound through a H(2)O(2)-dependent autocatalytic process. Heme insertion is important for the delivery of protein at the cell surface.
Cleaved in its N-terminal part.
Cellular localizationMembrane and Cell surface.
- Information by UniProt
- MSA antibody
- PERT_HUMAN antibody
- TDH2A antibody
ab12500 has been referenced in 3 publications.
- Muller I et al. Does thyroid peroxidase provide an antigenic link between thyroid autoimmunity and breast cancer? Int J Cancer 134:1706-14 (2014). PubMed: 24114667
- Cairns DM et al. Muscle cells enhance resistance to pro-inflammatory cytokine-induced cartilage destruction. Biochem Biophys Res Commun 392:22-8 (2010). PubMed: 20043873
- Cairns DM et al. The role of muscle cells in regulating cartilage matrix production. J Orthop Res 28:529-36 (2010). PubMed: 19813241