Overview

  • Product name

    TIC10 (ONC201), TRAIL activator
  • Description

    TRAIL activator
  • Alternative names

    • ONC201
  • Biological description

    TRAIL activator. Induces TRAIL via Akt and ERK inactivation. Induces apoptosis in cancer cells and healthy cells. Shows antitumor effects in vivo. Blood-brain barrier permeable.
  • Purity

    > 99%
  • CAS Number

    41276-02-2
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Allen JE  et al. Genetic and Pharmacological Screens Converge in Identifying FLIP, BCL2, and IAP Proteins as Key Regulators of Sensitivity to the TRAIL-Inducing Anticancer Agent ONC201/TIC10. Cancer Res 75:1668-74 (2015). Read more (PubMed: 25681273) »
  • Prabhu VV  et al. Small-Molecule ONC201/TIC10 Targets Chemotherapy-Resistant Colorectal Cancer Stem-like Cells in an Akt/Foxo3a/TRAIL-Dependent Manner. Cancer Res 75:1423-32 (2015). Read more (PubMed: 25712124) »
  • Wagner J  et al. The angular structure of ONC201, a TRAIL pathway-inducing compound, determines its potent anti-cancer activity. Oncotarget 5:12728-37 (2014). Read more (PubMed: 25587031) »

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