Key features and details
- Rabbit polyclonal to TICAM2
- Suitable for: WB, IHC-P
- Reacts with: Human
- Isotype: IgG
Product nameAnti-TICAM2 antibody
See all TICAM2 primary antibodies
DescriptionRabbit polyclonal to TICAM2
Tested applicationsSuitable for: WB, IHC-Pmore details
Species reactivityReacts with: Human
Fusion protein corresponding to Human TICAM2 (internal sequence). The identity of the protein fusion partner is GST. Gene Accssion: BC109266
Database link: Q86XR7
- HeLa, HT29 and PC3 cell lsyates, Human testis tissue lysate, Human thyroid cancer tissue
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferpH: 7.30
Preservative: 0.05% Sodium azide
Constituents: 50% Glycerol, 49% PBS
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab198023 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/200 - 1/1000. Predicted molecular weight: 27 kDa.|
|IHC-P||1/100 - 1/300.|
FunctionFunctions in LPS-TLR4 signaling to regulate the MYD88-independent pathway during the innate immune response to LPS. Also involved in IL1-triggered NF-kappa-B activation, functioning upstream of IRAK1, IRAK2, TRAF6, and IKBKB. Physically bridges TLR4 and TICAM1 and functionally transmits LPS-TRL4 signal to TICAM1.
Tissue specificityExpressed in spleen, prostate, testis, uterus, small intestine, colon, peripheral blood leukocytes, heart, placenta, lung, liver, skeletal muscle, and pancreas.
Sequence similaritiesContains 1 TIR domain.
DomainThe TIR domain mediates the interaction with TRAF6.
modificationsPhosphorylated by PKCE in response to LPS. Phosphorylation is essential for its function. It is depleted from the membrane upon phosphorylation.
Myristoylated. Required for membrane association which is critical for its ability to initiate efficient signaling.
Cellular localizationCytoplasm. Golgi apparatus. Cell membrane. Localized to the plasma membrane as a result of myristoylation. Phosphorylation on Ser-16 leads to its depletion from the membrane.
- Information by UniProt
- Putative NF-kappa-B-activating protein 502 antibody
- TCAM2_HUMAN antibody
- TICAM-2 antibody
All lanes : Anti-TICAM2 antibody (ab198023) at 1/200 dilution
Lane 1 : HeLa cell lysate
Lane 2 : Human testis cell lysate
Lane 3 : HT29 cell lysate
Lane 4 : PC3 cell lysate
Lysates/proteins at 40 µg per lane.
Predicted band size: 27 kDa
Exposure time: 20 seconds
Immunohistochemical analysis of paraffin-embedded Human thyroid cancer tissue labeling TICAM2 using ab198023 at 1/160 dilution.
ab198023 has not yet been referenced specifically in any publications.