Overview

  • Product name

  • Description

    Rabbit polyclonal to TICAM2
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, IHC-Pmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Fusion protein corresponding to Human TICAM2 (internal sequence). The identity of the protein fusion partner is GST. Gene Accssion: BC109266
    Database link: Q86XR7

  • Positive control

    • HeLa, HT29 and PC3 cell lsyates, Human testis tissue lysate, Human thyroid cancer tissue

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer

    pH: 7.3
    Preservative: 0.05% Sodium azide
    Constituents: 50% Glycerol, 49% PBS
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab198023 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/200 - 1/1000. Predicted molecular weight: 27 kDa.
IHC-P 1/100 - 1/300.

Target

  • Function

    Functions in LPS-TLR4 signaling to regulate the MYD88-independent pathway during the innate immune response to LPS. Also involved in IL1-triggered NF-kappa-B activation, functioning upstream of IRAK1, IRAK2, TRAF6, and IKBKB. Physically bridges TLR4 and TICAM1 and functionally transmits LPS-TRL4 signal to TICAM1.
  • Tissue specificity

    Expressed in spleen, prostate, testis, uterus, small intestine, colon, peripheral blood leukocytes, heart, placenta, lung, liver, skeletal muscle, and pancreas.
  • Sequence similarities

    Contains 1 TIR domain.
  • Domain

    The TIR domain mediates the interaction with TRAF6.
  • Post-translational
    modifications

    Phosphorylated by PKCE in response to LPS. Phosphorylation is essential for its function. It is depleted from the membrane upon phosphorylation.
    Myristoylated. Required for membrane association which is critical for its ability to initiate efficient signaling.
  • Cellular localization

    Cytoplasm. Golgi apparatus. Cell membrane. Localized to the plasma membrane as a result of myristoylation. Phosphorylation on Ser-16 leads to its depletion from the membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • Putative NF-kappa-B-activating protein 502 antibody
    • TCAM2_HUMAN antibody
    • TICAM-2 antibody
    • TICAM2 antibody
    • TIR containing adapter molecule 2 antibody
    • TIR domain containing adaptor protein antibody
    • TIR domain-containing adapter molecule 2 antibody
    • TIRAP 3 antibody
    • TIRAP3 antibody
    • TIRAP3a short form antibody
    • TIRP antibody
    • Toll-like receptor adaptor protein 3 antibody
    • Toll/interleukin-1 receptor domain-containing protein antibody
    • TRAM antibody
    • TRIF-related adapter molecule antibody
    see all

Images

  • All lanes : Anti-TICAM2 antibody (ab198023) at 1/200 dilution

    Lane 1 : HeLa cell lysate
    Lane 2 : Human testis cell lysate
    Lane 3 : HT29 cell lysate
    Lane 4 : PC3 cell lysate

    Lysates/proteins at 40 µg per lane.

    Predicted band size: 27 kDa


    Exposure time: 20 seconds
  • Immunohistochemical analysis of paraffin-embedded Human thyroid cancer tissue labeling TICAM2 using ab198023 at 1/160 dilution.

References

ab198023 has not yet been referenced specifically in any publications.

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