Anti-TIE1 antibody (ab64477)
Key features and details
- Rabbit polyclonal to TIE1
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-TIE1 antibody
See all TIE1 primary antibodies -
Description
Rabbit polyclonal to TIE1 -
Host species
Rabbit -
Tested applications
Suitable for: IHC-Pmore details -
Species reactivity
Reacts with: Human -
Immunogen
Synthetic peptide within Human TIE1 aa 550-650 (C terminal). The exact sequence is proprietary.
Database link: P35590 -
Positive control
- Human tonsil tissue
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General notes
Cell membrane staining pattern
This product is FOR RESEARCH USE ONLY. For commercial use, please contact partnerships@abcam.com.
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
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Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
Storage buffer
pH: 7.60
Preservative: 0.1% Sodium azide
Constituents: PBS, 1% BSA -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab64477 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
---|---|---|
IHC-P | (1) |
1/100.
1/100 for 30 min at room temperature. |
Notes |
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IHC-P
1/100. 1/100 for 30 min at room temperature. |
Target
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Function
Transmembrane tyrosine-protein kinase that may modulate TEK/TIE2 activity and contribute to the regulation of angiogenesis. -
Tissue specificity
Specifically expressed in developing vascular endothelial cells. -
Sequence similarities
Belongs to the protein kinase superfamily. Tyr protein kinase family. Tie subfamily.
Contains 3 EGF-like domains.
Contains 3 fibronectin type-III domains.
Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
Contains 1 protein kinase domain. -
Post-translational
modificationsPhosphorylated on tyrosine residues in response to ANGPT1, most likely by TEK/TIE2. -
Cellular localization
Cell membrane. - Information by UniProt
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Database links
- Entrez Gene: 7075 Human
- Omim: 600222 Human
- SwissProt: P35590 Human
- Unigene: 78824 Human
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Alternative names
- JKT 14 antibody
- JTK14 antibody
- TIE antibody
see all
Images
Datasheets and documents
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SDS download
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Datasheet download
References (2)
ab64477 has been referenced in 2 publications.
- Sopo M et al. High expression of Tie-2 predicts poor prognosis in primary high grade serous ovarian cancer. PLoS One 15:e0241484 (2020). PubMed: 33151982
- Allerkamp H et al. Characterization of a Porcine Model for Von Willebrand Disease Type 1 and 3 Regarding Expression of Angiogenic Mediators in the Nonpregnant Female Reproductive Tract. Comp Med 69:401-412 (2019). PubMed: 31526432