Key features and details
- Potent, reversible and selective ATP-binding site-targeting Tie2 kinase inhibitor. Cell-permeable.
- CAS Number: 948557-43-5
- Purity: > 99%
- Soluble in DMSO to 50 mM
- Form / State: Solid
- Source: Synthetic
Product nameTie2 kinase inhibitor, ATP-binding site-targeting Tie2 kinase inhibitor. Cell-permeable.
DescriptionPotent, reversible and selective ATP-binding site-targeting Tie2 kinase inhibitor. Cell-permeable.
Potent, reversible and selective ATP-binding site-targeting Tie2 kinase inhibitor (IC50 = 250 nM). Anti- angiogenesis agent. Active in vivo and in vivo. Cell-permeable.
Storage instructionsStore at +4°C. The product can be stored for up to 12 months.
Solubility overviewSoluble in DMSO to 50 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
- Receptors & Transporters
- Enzyme-Linked Receptors
- Receptor tyrosine kinases
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab141270 has been referenced in 1 publication.
- Besnier M et al. miR-15a/-16 Inhibit Angiogenesis by Targeting the Tie2 Coding Sequence: Therapeutic Potential of a miR-15a/16 Decoy System in Limb Ischemia. Mol Ther Nucleic Acids 17:49-62 (2019). PubMed: 31220779