Product nameTiliroside, CYP inhibitor
DescriptionReversible, competitive CYP inhibitor. Anti-inflammatory and antioxidant agent.
Biological descriptionAnti-inflammatory and antioxidant agent. Reversible, competitive CYP inhibitor (IC50 values are 9, 10 and 12 μM for CYP3A4, CYP2C9 and CYP2C8 respectively). Inhibts NO, TNF-α and IL-12 production in activated macrophages. Antihypertensive and antiobesigenic effects in vivo. Orally active.
Chemical name[(2R,3S,4S,5R,6S)-6-[5,7-dihydroxy-2-(4-hydroxyphenyl)-4-oxochromen-3-yl]oxy-3,4,5-trihydroxyoxan-2-yl]methyl (E)-3-(4-hydroxyphenyl)prop-2-enoate
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in DMSO and in ethanol
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
- Signal transduction
- Nitric oxide & oxidative stress
This product has been referenced in:
- Silva GC et al. Mechanism of the antihypertensive and vasorelaxant effects of the flavonoid tiliroside in resistance arteries. Planta Med 79:1003-8 (2013). Read more (PubMed: 23877918) »
- Sun DX et al. Reversible inhibition of three important human liver cytochrome p450 enzymes by tiliroside. Phytother Res 24:1670-5 (2010). Read more (PubMed: 21031626) »
- Ninomiya K et al. Potent anti-obese principle from Rosa canina: structural requirements and mode of action of trans-tiliroside. Bioorg Med Chem Lett 17:3059-64 (2007). Read more (PubMed: 17400451) »