Overview

  • Product name

    Tiliroside, CYP inhibitor
  • Description

    Reversible, competitive CYP inhibitor. Anti-inflammatory and antioxidant agent.
  • Biological description

    Anti-inflammatory and antioxidant agent. Reversible, competitive CYP inhibitor (IC50 values are 9, 10 and 12 μM for CYP3A4, CYP2C9 and CYP2C8 respectively). Inhibts NO, TNF-α and IL-12 production in activated macrophages. Antihypertensive and antiobesigenic effects in vivo. Orally active.
  • Purity

    > 98%
  • CAS Number

    20316-62-5
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Silva GC  et al. Mechanism of the antihypertensive and vasorelaxant effects of the flavonoid tiliroside in resistance arteries. Planta Med 79:1003-8 (2013). Read more (PubMed: 23877918) »
  • Sun DX  et al. Reversible inhibition of three important human liver cytochrome p450 enzymes by tiliroside. Phytother Res 24:1670-5 (2010). Read more (PubMed: 21031626) »
  • Ninomiya K  et al. Potent anti-obese principle from Rosa canina: structural requirements and mode of action of trans-tiliroside. Bioorg Med Chem Lett 17:3059-64 (2007). Read more (PubMed: 17400451) »

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