• Product name
  • Description
    Rabbit polyclonal to TIMM8A
  • Host species
  • Tested applications
    Suitable for: IPmore details
    Unsuitable for: WB
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rabbit, Guinea pig, Chimpanzee, Cynomolgus monkey, Rhesus monkey, Gorilla, Orangutan
  • Immunogen

    Synthetic peptide, corresponding to a region within amino acids 1-50 of Human TIMM8A (NP_004076.1).

  • Positive control
    • 293T whole cell lysate.



Our Abpromise guarantee covers the use of ab168835 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IP Use at 2-10 µg/mg of lysate.
  • Application notes
    Is unsuitable for WB.
  • Target

    • Function
      Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The TIMM8-TIMM13 complex mediates the import of proteins such as TIMM23, SLC25A12/ARALAR1 and SLC25A13/ARALAR2, while the predominant TIMM9-TIMM10 70 kDa complex mediates the import of much more proteins. Probably necessary for normal neurologic development.
    • Tissue specificity
      Highly expressed in fetal and adult brain, followed by fetal lung, liver and kidney. Also expressed in heart, placenta, lung, liver, kidney, pancreas, skeletal muscle and heart.
    • Involvement in disease
      Defects in TIMM8A are the cause of Mohr-Tranebjaerg syndrome (MTS) [MIM:304700]; also known as dystonia-deafness syndrome (DDS) or X-linked progressive deafness type 1 (DFN-1). It is a recessive neurodegenerative syndrome characterized by postlingual progressive sensorineural deafness as the first presenting symptom in early childhood, followed by progressive dystonia, spasticity, dysphagia, mental deterioration, paranoia and cortical blindness.
      Defects in TIMM8A are the cause of Jensen syndrome (JENSS) [MIM:311150]; also known as opticoacoustic nerve atrophy with dementia. This X-linked disease is characterized by deafness, blindness and muscle weakness.
    • Sequence similarities
      Belongs to the small Tim family.
    • Domain
      The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. However, during the transit of TIMM8A from cytoplasm into mitochondrion, the Cys residues probably coordinate zinc, thereby preventing folding and allowing its transfer across mitochondrial outer membrane.
    • Cellular localization
      Mitochondrion inner membrane.
    • Information by UniProt
    • Database links
    • Alternative names
      • DDP 1 antibody
      • DDP antibody
      • DDP1 antibody
      • Deafness dystonia protein 1 antibody
      • Deafness/dystonia peptide antibody
      • DFN 1 antibody
      • DFN1 antibody
      • MGC12262 antibody
      • Mitochondrial import inner membrane translocase subunit Tim8 A antibody
      • MTS antibody
      • TIM 8A antibody
      • TIM8 antibody
      • TIM8A antibody
      • TIM8A_HUMAN antibody
      • TIMM 8A antibody
      • timm8a antibody
      • Translocase of inner mitochondrial membrane 8 homolog A antibody
      • X linked deafness dystonia protein antibody
      • X-linked deafness dystonia protein antibody
      see all


    • Detection of TIMM8A in Immunoprecipitates of 293T whole cell lysate (1 mg for IP, 20% of IP loaded) using ab168835 at 6 µg/mg lysate for IP and at 1 µg/ml for subsequent Western blot detection.
      Detection: Chemiluminescence with an exposure time of 3 minutes.

      Predicted MWt 11 kDa.


    ab168835 has not yet been referenced specifically in any publications.

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