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Cell Biology Apoptosis Extracellular Signals Granzymes
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Anti-TIMP3 antibody - C-terminal (ab231495)

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TIMP3 antibody - C-terminal (ab231495)

    Key features and details

    • Rabbit polyclonal to TIMP3 - C-terminal
    • Suitable for: IHC-P
    • Reacts with: Human
    • Isotype: IgG

    You may also be interested in

    Protein
    Product image
    Recombinant Human TIMP3 protein (ab159704)
    Secondary
    Product image
    Goat Anti-Rabbit IgG H&L (HRP) (ab205718)

    View more associated products

    Overview

    • Product name

      Anti-TIMP3 antibody - C-terminal
      See all TIMP3 primary antibodies
    • Description

      Rabbit polyclonal to TIMP3 - C-terminal
    • Host species

      Rabbit
    • Tested applications

      Suitable for: IHC-Pmore details
    • Species reactivity

      Reacts with: Human
      Predicted to work with: Mouse, Rat, Chicken, Cow, Dog
    • Immunogen

      Synthetic peptide within Human TIMP3 aa 150 to the C-terminus (C terminal). The exact sequence is proprietary.
      Database link: P35625

    • Positive control

      • IHC-P: Human placenta tissue.
    • General notes

      This product is FOR RESEARCH USE ONLY. For commercial use, please contact partnerships@abcam.com.

      Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.

      Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.

      We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.

      In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.

      We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.

      Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.

      Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.

    Properties

    • Form

      Liquid
    • Storage instructions

      Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
    • Storage buffer

      pH: 7.60
      Preservative: 0.1% Sodium azide
      Constituents: PBS, 1% BSA
    • Concentration information loading...
    • Purity

      Immunogen affinity purified
    • Clonality

      Polyclonal
    • Isotype

      IgG
    • Research areas

      • Cell Biology
      • Apoptosis
      • Extracellular Signals
      • Granzymes
      • Cardiovascular
      • Angiogenesis
      • Adhesion / ECM
      • Matrix Metalloproteinases
      • TIMP
      • Signal Transduction
      • Cytoskeleton / ECM
      • Extracellular Matrix
      • ECM Enzymes
      • MMP Inhibitors
      • Neuroscience
      • Sensory System
      • Visual system
      • Cancer
      • Invasion/microenvironment
      • Angiogenesis
      • ECM enzymes
      • TIMPs
      • Cancer
      • Invasion/microenvironment
      • ECM
      • Extracellular matrix
      • TIMPs
      • Cell Biology
      • Proteolysis / Ubiquitin
      • Protease inhibitors
      • Metalloprotease inhibitors
      • TIMPs

    Associated products

    • Compatible Secondaries

      • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
      • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
    • Isotype control

      • Rabbit IgG, polyclonal - Isotype Control (ChIP Grade) (ab171870)
    • Recombinant Protein

      • Recombinant Human TIMP3 protein (ab159704)
    • Related Products

      • Recombinant Human TIMP3 protein (ab159704)

    Applications

    Our Abpromise guarantee covers the use of ab231495 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Abreviews Notes
    IHC-P 1/70. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

    Primary antibody incubation for 10 minutes at room temperature.

    Target

    • Function

      Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-13, MMP-14 and MMP-15.
    • Involvement in disease

      Defects in TIMP3 are the cause of Sorsby fundus dystrophy (SFD) [MIM:136900]. SFD is a rare autosomal dominant macular disorder with an age of onset in the fourth decade. It is characterized by loss of central vision from subretinal neovascularization and atrophy of the ocular tissues. Generally, macular disciform degeneration develops in the patients eye within 6 months to 6 years.
    • Sequence similarities

      Belongs to the protease inhibitor I35 (TIMP) family.
      Contains 1 NTR domain.
    • Cellular localization

      Secreted > extracellular space > extracellular matrix.
    • Target information above from: UniProt accession P35625 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt
    • Database links

      • Entrez Gene: 396483 Chicken
      • Entrez Gene: 282094 Cow
      • Entrez Gene: 481289 Dog
      • Entrez Gene: 7078 Human
      • Entrez Gene: 21859 Mouse
      • Entrez Gene: 25358 Rat
      • Omim: 188826 Human
      • SwissProt: P79121 Cow
      • SwissProt: P35625 Human
      • SwissProt: P39876 Mouse
      • SwissProt: P48032 Rat
      • Unigene: 644633 Human
      • Unigene: 714168 Human
      • Unigene: 4871 Mouse
      • Unigene: 119634 Rat
      see all
    • Alternative names

      • HSMRK222 antibody
      • K222 antibody
      • K222TA2 antibody
      • Metalloproteinase inhibitor 3 antibody
      • MIG 5 protein antibody
      • MIG5 protein antibody
      • Protein MIG 5 antibody
      • Protein MIG-5 antibody
      • SFD antibody
      • Sorsby fundus dystrophy pseudoinflammatory antibody
      • TIMP 3 antibody
      • TIMP metallopeptidase inhibitor 3 antibody
      • TIMP-3 antibody
      • TIMP3 antibody
      • TIMP3_HUMAN antibody
      • Tissue Inhibitor of Metalloproteinase 3 antibody
      • Tissue inhibitor of metalloproteinases 3 antibody
      • Tissue inhibitor of metalloproteinases3 antibody
      see all

    Images

    • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TIMP3 antibody - C-terminal (ab231495)
      Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TIMP3 antibody - C-terminal (ab231495)

      Formalin-fixed, paraffin-embedded human placenta tissue stained for TIMP3 using ab231495 at 1/70 dilution in immunohistochemical analysis.

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    Datasheets and documents

    • Datasheet
  • References (0)

    Publishing research using ab231495? Please let us know so that we can cite the reference in this datasheet.

    ab231495 has not yet been referenced specifically in any publications.

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