Overview

  • Product name

  • Description

    Rabbit polyclonal to Tin2
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Recombinant fragment corresponding to Human Tin2 aa 210-451.
    Database link: Q9BSI4

  • Positive control

    • IHC-P: Human placenta tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab238333 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/20 - 1/200.

Target

  • Function

    Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Plays a role in shelterin complex assembly.
  • Tissue specificity

    Detected in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
  • Involvement in disease

    Defects in TINF2 are a cause of dyskeratosis congenita autosomal dominant (ADDKC) [MIM:127550]; also known as dyskeratosis congenita Scoggins type. ADDKC is a rare, progressive bone marrow failure syndrome characterized by the triad of reticulated skin hyperpigmentation, nail dystrophy, and mucosal leukoplakia. Early mortality is often associated with bone marrow failure, infections, fatal pulmonary complications, or malignancy.
    Defects in TINF2 are a cause of retinopathy exudative with bone marrow failure (ERBMF) [MIM:268130]; also known as Revesz syndrome. ERBMF is characterized by bilateral exudative retinopathy, bone marrow hypoplasia, nail dystrophy, fine hair, cerebellar hypoplasia, and growth retardation.
  • Domain

    The TBM domain mediates interaction with TERF1.
  • Cellular localization

    Nucleus. Chromosome > telomere. Associated with telomeres.
  • Information by UniProt
  • Database links

  • Alternative names

    • AW552114 antibody
    • D14Wsu146e antibody
    • DKCA3 antibody
    • MGC94711 antibody
    • TERF 1 (TRF 1) interacting nuclear factor 2 antibody
    • TERF 1 interacting nuclear factor 2 antibody
    • TERF1 (TRF1) interacting nuclear factor 2 antibody
    • TERF1 interacting nuclear factor 2 antibody
    • TERF1-interacting nuclear factor 2 antibody
    • Tin 2 antibody
    • TIN2 antibody
    • TINF 2 antibody
    • Tinf2 antibody
    • TINF2_HUMAN antibody
    • TRF 1 interacting nuclear factor 2 antibody
    • TRF1 interacting nuclear factor 2 antibody
    • TRF1-interacting nuclear protein 2 antibody
    see all

Images

  • Paraffin-embedded human placenta tissue stained for Tin2 with ab238333 at a 1/100 dilution in immunohistochemical analysis.

References

ab238333 has not yet been referenced specifically in any publications.

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